Associated Genetic Biomarkers

Overview

NCI Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. [1]

Acute lymphoblastic leukemias most frequently harbor alterations in WT1, NOTCH1, EZH2, BCORL1, and USP7 [2].

Most Commonly Altered Genes in Acute Lymphoblastic Leukemia

WT1fs, NOTCH1 Mutation, NOTCH1 Missense, EZH2 Mutation, and EZH2 Exon 19 Mutation are the most common alterations in acute lymphoblastic leukemia [2].

Top Alterations in Acute Lymphoblastic Leukemia

Significant Genes in Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

ATM +

BCL2 +

BCL6 +

BCOR +

BCR +

BIRC3 +

CBFA2T3 +

CBFB +

CEP72 +

CREBBP +

CRLF2 +

CSF1R +

DEK +

DNMT3A +

ELL +

EPOR +

ETV6 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

GLIS2 +

HIP1 +

HOXA9 +

HRAS +

IGH +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

LYN +

MAF +

MAFB +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYH11 +

NPM1 +

NRAS +

NRIP3 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUP98 +

PBX1 +

PDGFRA +

PDGFRB +

PHF6 +

PML +

PPM1D +

PRDM16 +

RARA +

RET +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

SMARCA4 +

SMARCB1 +

TCF3 +

TET2 +

TP53 +

TRA +

TRB +

TRD +

TRG +

TYK2 +

WHSC1 +

WT1 +

Disease Details

Synonyms
Precursor Lymphoblasic Leukemia, Acute Lymphocytic Leukaemia, Acute Lymphoid Leukemia, Lymphoblastic Leukemia, ALL - Acute Lymphocytic Leukemia, Acute Lymphocytic Leukemias, Acute Lymphogenous Leukemia, Acute lymphoblastic leukemia, NOS, LEUKEMIA, LYMPHOBLASTIC, MALIGNANT, Precursor Cell Lymphoblastic Leukemia, ALL, Acute Lymphocytic Leukemia, Precursor Lymphoblastic Leukemia
Parent(s)
Precursor Lymphoid Neoplasm
Children
T-Cell Acute Lymphoblastic Leukemia, Adult Acute Lymphoblastic Leukemia, and B-Cell Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.