Overview

Variant Type
Fusion
Genes
RUNX1T1 and RUNX1

RUNX1-RUNX1T1 Fusion is present in 0.20% of AACR GENIE cases, with lung adenocarcinoma, acute myeloid leukemia, breast invasive ductal carcinoma, acute myeloid leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1, and adenocarcinoma of the gastroesophageal junction having the greatest prevalence [4].

Top Disease Cases with RUNX1-RUNX1T1 Fusion

Significance of RUNX1-RUNX1T1 Fusion in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Non-Hodgkin Lymphoma +

Chronic Lymphocytic Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Acute Biphenotypic Leukemia +

Chronic Myelomonocytic Leukemia +

Myeloproliferative Neoplasm +

Refractory Anemia With Excess Blasts +

Acute Promyelocytic Leukemia +

Double-Hit Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Small Lymphocytic Lymphoma +

Acute Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Acute Myeloid Leukemia With t(8;21); (Q22; Q22.1); RUNX1-RUNX1T1 +

Core Binding Factor Acute Myeloid Leukemia +

Lymphoma +

Acute Myeloid Leukemia With Inv(16)(P13.1q22) Or t(16;16)(P13.1;Q22); CBFB-MYH11 +

Adult T-Cell Leukemia/Lymphoma +

Anaplastic Large Cell Lymphoma +

Aplastic Anemia +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

B-Cell Non-Hodgkin Lymphoma +

Burkitt Lymphoma +

Diffuse Large B-Cell Lymphoma +

Follicular Lymphoma +

Juvenile Myelomonocytic Leukemia +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Mantle Cell Lymphoma +

Marginal Zone Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelofibrosis +

Prolymphocytic Leukemia +

Refractory Anemia +

Secondary Acute Myeloid Leukemia +

Small Lymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.