Diseases /
Alveolar Rhabdomyosarcoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities. [1]
Alveolar rhabdomyosarcomas most frequently harbor alterations in FOXO1, PAX3, MYCN, PAX7, and MYCL [2].
FOXO1 Fusion, PAX3-FOXO1 Fusion, FOXO1-PAX3 Fusion, MYCN Amplification, and PAX7-FOXO1 Fusion are the most common alterations in alveolar rhabdomyosarcoma [2].
Clinical Trials
Significant Genes in Alveolar Rhabdomyosarcoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.