Overview

NCI Definition: A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001) [1]

Anaplastic large cell lymphomas most frequently harbor alterations in ALK, STAT3, TP53, SF3B1, and MTOR [2].

Most Commonly Altered Genes in Anaplastic Large Cell Lymphoma

ALK Fusion, STAT3 Mutation, SF3B1 Mutation, MTOR Amplification, and IRF4 Amplification are the most common alterations in anaplastic large cell lymphoma [2].

Top Alterations in Anaplastic Large Cell Lymphoma

Significant Genes in Anaplastic Large Cell Lymphoma

ABL1 +

AFF1 +

ALK +

BCR +

BIRC2 +

BIRC3 +

CARD11 +

CBFB +

CCND1 +

CD79A +

CD79B +

DEK +

ELL +

FLT3 +

IGH +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NFKBIA +

NPM1 +

NRIP3 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PBX1 +

ROS1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TNFAIP3 +

TP53 +

Disease Details

Synonyms
CD30 Positive Anaplastic Large Cell Lymphoma, Ki-1+ Anaplastic Large Cell Lymphoma, ALCL, Lymph node anaplastic large cell lymphoma, Ki-1 Lymphoma, Ki-1+ ALCL
Parent(s)
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
Children
Systemic Anaplastic Large Cell Lymphoma, Primary Cutaneous Anaplastic Large Cell Lymphoma, Anaplastic Large Cell Lymphoma, ALK-Negative, and Anaplastic Large Cell Lymphoma, ALK-Positive
OncoTree Name
Anaplastic Large Cell Lymphoma
OncoTree Code
ALCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.