Diseases /
Appendix Neuroendocrine Tumor
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Associated Genetic Biomarkers
Overview
NCI Definition: A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the appendix. [1]
Appendix neuroendocrine tumors most frequently harbor alterations in SMAD4, KRAS, YES1, SPOP, and SMARCA4 [2].
KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, YES1 Loss, and SPOP Y87C are the most common alterations in appendix neuroendocrine tumor [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.