Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [1]

Gliomas most frequently harbor alterations in TP53, IDH1, CDKN2A, PTEN, and EGFR [2].

Most Commonly Altered Genes in Glioma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in glioma [2].

Top Alterations in Glioma

Significant Genes in Glioma

ARAF +

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

CRKL +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

H3F3A +

HGF +

HRAS +

IDH1 +

IDH2 +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MET +

MRE11A +

MYCN +

NBN +

NF1 +

NRAS +

PALB2 +

PDGFRA +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

SLX4 +

SRC +

TACC1 +

TACC3 +

Disease Details

Synonyms
NEUROGLIAL TUMOR, UNDETERMINED, Neuroglial Tumor, Neoplasm of the Neuroglia, Glial Neoplasm, Neoplasm of Neuroglia, Brain glioma (NOS), Tumor of Neuroglia, PEDIATRIC Brain glioma (NOS), Tumor of the Neuroglia, Neoplasms of Neuroglia, Tumors of Neuroglia, Neuroglial Neoplasms, Neuroglial Neoplasm, Glial Tumor, Recurrent high-grade glioma
Parent(s)
Neuroepithelial Neoplasm
Children
Oligodendroglial Tumor, Low Grade Glioma, Astrocytic Tumor, Diffuse Glioma, Optic Nerve Glioma, Astroblastoma, Brain Stem Glioma, Encapsulated Glioma, Malignant Glioma, Ependymal Tumor, Chordoid Glioma of the Third Ventricle, and Spinal Cord Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.