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High Grade Ovarian Serous Adenocarcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A rapidly growing serous adenocarcinoma that arises from the ovary. It is characterized by the presence of high grade cytologic features and frequent mitotic figures. [1]
High grade ovarian serous adenocarcinomas most frequently harbor alterations in TP53, CCNE1, BRCA1, NF1, and MYC [2].
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Exon 5 Mutation, and TP53 Exon 7 Mutation are the most common alterations in high grade ovarian serous adenocarcinoma [2].
Significant Genes in High Grade Ovarian Serous Adenocarcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.