Diseases /
Inflammatory Myofibroblastic Tumor
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Associated Genetic Biomarkers
Overview
NCI Definition: A multinodular intermediate fibroblastic neoplasm that arises from soft tissue or viscera, in children and young adults. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [1]
Inflammatory myofibroblastic tumors most frequently harbor alterations in ALK, TFG, ROS1, RANBP2, and NOTCH1 [2].
ALK Fusion, TFG-ROS1 Fusion, ROS1 Fusion, RANBP2-ALK Fusion, and KRAS Mutation are the most common alterations in inflammatory myofibroblastic tumor [2].
Biomarker-Directed Therapies
Significant Genes in Inflammatory Myofibroblastic Tumor
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.