Diseases /
Waldenstrom Macroglobulinemia
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Associated Genetic Biomarkers
Overview
NCI Definition: Lymphoplasmacytic lymphoma associated with bone marrow involvement and IgM monoclonal gammopathy. [1]
Waldenstrom macroglobulinemias most frequently harbor alterations in MYD88, DNMT3A, TET2, RUNX1, and PMS1 [2].
MYD88 Mutation, MYD88 L265P, MYD88 Exon 5 Mutation, DNMT3A Mutation, and DNMT3A Nonsense are the most common alterations in waldenstrom macroglobulinemia [2].
Clinical Trials
Significant Genes in Waldenstrom Macroglobulinemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.