Overview

CD44 molecule (Indian blood group) (CD44) is a gene that encodes a protein that functions in cell-cell interactions, cell adhesion, cell migration, lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Missense mutations, synonymous mutations, frameshift deletions, and nonsense mutations are observed in cancers such as stomach cancer, endometrial cancer, and lung cancer.

CD44 is altered in 0.00% of all cancers with pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

Significance of CD44 in Diseases

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.