Overview

CD58 molecule (CD58) is a gene that encodes a protein that belongs to the immunoglobulin superfamily. The protein functions as a ligand of the T lymphocyte CD2 protein. The protein is also important for adhesion and activation of T lymphocytes. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions and deletions are observed in cancers such as intestinal cancer, stomach cancer, and cancers of the urinary tract.

CD58 is altered in 0.35% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, colon adenocarcinoma, lung adenocarcinoma, mantle cell lymphoma, and peripheral T-cell lymphoma, not otherwise specified having the greatest prevalence of alterations [3].

The most common alterations in CD58 are CD58 Loss (0.31%), CD58 G210S (0.04%), CD58 M1? (0.07%), CD58 X210_splice (0.04%), and CD58 X24_splice (0.03%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.