Overview

Centriolin (CNTRL; also known as CEP110) is a gene that encodes a centrosomal protein that functions as a microtubule organizing center. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as Hematopoietic and lymphoid cancers, lung cancer, and ovarian cancer.

CNTRL is altered in 0.09% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, prostate adenocarcinoma, dysembryoplastic neuroepithelial tumor, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

The most common alteration in CNTRL is CNTRL-FGFR1 Fusion (0.22%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.