Biomarkers /
CRLF2
Overview
CRLF2 (cytokine receptor-like factor 2) is a gene that encodes for the protein cytokine receptor-like factor 2, a receptor protein that participates in activating STAT (signal transducer and activator of transcription) signaling. In cancer, CRLF2 rearrangements and one recurring mutation leading to CRLF2 overexpression have been identified in a subset of patients with high risk acute lymphoblastic leukemia who have an exceptionally dismal prognosis.
CRLF2 is altered in 1.04% of all cancers with lung adenocarcinoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].
The most common alterations in CRLF2 are CRLF2 Loss (0.61%), CRLF2 Mutation (0.34%), CRLF2 Amplification (0.11%), CRLF2 S128L (0.03%), and CRLF2 Fusion (0.02%) [3].
Clinical Trials
Significance of CRLF2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.