Overview

FEV (ETS oncogene family) (FEV) is a gene that encodes a transcription factor protein that binds purine-rich DNA sequences. The protein may act as a transcription repressor. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, peritoneal cancer, and stomach cancer.

FEV is altered in 0.07% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, glioblastoma, Ewing sarcoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

The most common alterations in FEV are FEV-EWSR1 Fusion (0.01%) and FEV-FUS Fusion (0.01%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.