Overview

Forkhead box O3 (FOXO3) is a gene that encodes a protein that functions as a transcriptional activator. The protein transcriptionally initiates apoptosis in the absence of survival factors. Fusions, missense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FOXO3 is altered in 1.29% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, pancreatic adenocarcinoma, and glioblastoma having the greatest prevalence of alterations [3].

The most common alterations in FOXO3 are FOXO3 P456Q (20.13%), FOXO3 Amplification (2.02%), FOXO3 G424S (1.16%), FOXO3 Loss (0.37%), and FOXO3 S26C (0.14%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.