Overview

GATA binding protein 4 (GATA4) is a gene that encodes a protein that functions as a transcription factor. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and stomach cancer.

GATA4 is altered in 1.78% of all cancers with lung adenocarcinoma, colon adenocarcinoma, esophageal adenocarcinoma, breast invasive ductal carcinoma, and adenocarcinoma of the gastroesophageal junction having the greatest prevalence of alterations [3].

The most common alterations in GATA4 are GATA4 Amplification (0.37%), GATA4 Loss (0.33%), GATA4 P407R (0.04%), GATA4 E313D (0.03%), and GATA4 A286V (0.06%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.