Overview

GATA binding protein 6 (GATA6) is a gene that encodes a zinc finger transcription factor that functions in the regulation of cellular differentiation and organogenesis. Missense mutations, synonymous mutations, nonsense mutations, inframe deletions, frameshift insertions, frameshift deletions, and complex mutations are observed in cancers such as peritoneal cancer, colon cancer, and urinary tract cancer.

GATA6 is altered in 2.04% of all cancers with lung adenocarcinoma, colon adenocarcinoma, esophageal adenocarcinoma, endometrial endometrioid adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

The most common alterations in GATA6 are GATA6 Amplification (0.43%), GATA6 Loss (0.07%), GATA6 A178_A183del (0.07%), GATA6 Fusion (0.07%), and GATA6 G280A (0.07%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.