Overview

Leucine-zipper-like transcription regulator 1 (LZTR1) is a gene that encodes a protein that is believed to help stabilize the Golgi complex. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as endometrial cancer, skin cancer, and colon cancer.

LZTR1 is altered in 0.53% of all cancers with colon adenocarcinoma, conventional glioblastoma multiforme, cutaneous melanoma, lung adenocarcinoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].

The most common alterations in LZTR1 are LZTR1 Amplification (0.55%), LZTR1 G248R (0.13%), LZTR1 R412C (0.15%), LZTR1 T163M (0.15%), and LZTR1 R118H (0.11%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.