Overview

3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) is a gene that encodes the sulfate donor cosubstrate for all sulfotransferase enzymes. Missense mutations, synonymous mutations, and nonsense mutations are observed in cancers such as colon cancer, endometrial cancer, and stomach cancer.

PAPSS1 is altered in 0.13% of all cancers with low-grade glioma, NOS, pancreatic adenocarcinoma, pilocytic astrocytoma, thyroid gland papillary carcinoma, and astrocytoma having the greatest prevalence of alterations [3].

The most common alterations in PAPSS1 are PAPSS1-BRAF Fusion (0.14%) and PAPSS1-TET2 Fusion (0.04%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.