Overview

Phophoinositide-3-kinase, regulatory subunit 3 (gamma) (PIK3R3) is a gene that encodes a protein that functions in the regulation of phosphatidylinositol 3-kinase activity. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

PIK3R3 is altered in 0.69% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

The most common alterations in PIK3R3 are PIK3R3 Mutation (0.48%), PIK3R3 Amplification (0.10%), PIK3R3 M295* (0.04%), PIK3R3 Loss (0.03%), and PIK3R3 A449T (0.02%) [3].

Significance of PIK3R3 in Diseases

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.