Biomarkers /
PPP2R1A
Overview
Protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A) is a gene that encodes a protein that is a subunit of protein phosphatase 2, a complex implicated in the negative control of cell growth and division. Missense mutations, silent mutations, frameshift deletions, and nonsense mutations are observed in cancers such as endometrial cancer, colon cancer, and vulvar cancer.
PPP2R1A is altered in 1.82% of all cancers with endometrial serous adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in PPP2R1A are PPP2R1A Mutation (1.49%), PPP2R1A Amplification (0.26%), PPP2R1A P179R (0.22%), PPP2R1A R183W (0.20%), and PPP2R1A S256F (0.16%) [3].
Clinical Trials
Significance of PPP2R1A in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.