Overview

Slit guidance ligand 2 (SLIT2) is a gene that encodes a protein that functions in axon guidance and neuronal migration. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as stomach cancer, lung cancer, and colon cancer.

SLIT2 is altered in 0.84% of all cancers with cutaneous melanoma, conventional glioblastoma multiforme, lung adenocarcinoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

The most common alterations in SLIT2 are SLIT2 S373F (0.13%), SLIT2 D1076N (0.10%), SLIT2 D714E (0.18%), SLIT2 H959Y (0.11%), and SLIT2 R1216C (0.18%) [3].

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.