Biomarkers /
SRC
Overview
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) is a gene that encodes a protein that functions in the regulation of embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
SRC is altered in 1.07% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, rectal adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].
The most common alterations in SRC are SRC Mutation (0.59%), SRC Amplification (0.60%), SRC Loss (0.07%), SRC E527K (0.02%), and SRC R271W (0.09%) [3].
Clinical Trials
Significance of SRC in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.