Anticancer Agents


Kinase Inhibitors
Target Development Name(s) Generic Name(s) Trade
Name(s)
Notes
ABL AMN107 nilotinib Tasigna  
AP24534​ ponatinib Iclusig  
AS703569, R763 cenisertib    
AT9283​      
BMS-354825 dasatinib Sprycel  
INNO-406, NS-​187 bafetinib​    
SKI-606 bosutinib Bosulif  
STI-571, CGP57148, CGP57148B​ imatinib​ Gleevec  
XL228    
AKT AS703569, R763 cenisertib   catalytic inhibitor
AT13148      
AZD5363     catalytic inhibitor
BAY1125976      
GDC-0068 ipatasertib   catalytic inhibitor​
GSK2110183 afuresertib    
GSK2141795 uprosertib    
MK-2206     allosteric inhibitor
ALK
(Anaplastic Lymphoma Kinase)
ACE-041 dalantercept    
AP26113      
ASP2215 gilteritinib    
ASP3026      
CH5424802, RO5424802, AF802 alectinib    
LDK378 ceritinib Zykadia  
PF-02341066 crizotinib Xalkori  
PF-06463922      
RXDX-101      
TSR-011      
X-396      
Aurora A AS703569, R763 cenisertib    
AT9283      
ENMD-2076      
MK5108      
MLN8237 alisertib    
PF-03814735      
TAK901      
Aurora B AS703569, R763 cenisertib    
AT9283      
AZD1152-HQPA, AZD1152 barasertib    
GSK1070916      
PF-03814735      
Aurora C GSK1070916      
Aurora A/B/C ABT-348 ilorasertib    
AMG900      
BI 847325      
PHA-739358 danusertib    
SNS-314      
AXL ASP2215 gilteritinib    
MGCD265      
MGCD516      
BRAF ARQ 736      
GSK2118436 dabrafenib Tafinlar  
PLX-4032, RG7204, R05185426 vemurafenib Zelboraf  
RAF265      
RO5212054, PLX3603      
BTK AS703569, R763 cenisertib    
AVL-292      
PCI-32765 ibrutinib Imbruvica  
CDK 1,2,4,5,6,7,9 (pan-CDK) HMR-1275, L868275, flavopiridol alvocidib    
CDK 1,2,4,7,9 (pan-CDK) BAY 1000349 roniciclib    
CDK 1,2,5,9 SCH727965 dinaciclib    
CDK 2,7,9 CYC202 seliciclib    
CDK 4,6 LEE011 ribociclib    
LY2835219 abemaciclib    
PD 0332991 palbociclib Ibrance  
CHEK1 LY2606368      
CHEK2 LY2603618 rabusertib    
CSF-1R PLX3397, PLX108-01      
PLX7486      
DDR2 MGCD516      
EGFR (HER1/ERBB1) AEE788, NVP-AEE788      
AP26113     wild type-sparing EGFR inhibitor
ASP8273     wild type-sparing EGFR inhibitor
AZD6474, ZD6474 vandetanib Zactima, Caprelsa  
AZD9291     wild type-sparing EGFR inhibitor
BIBW-2992 afatinib Gilotrif, Tomtovok  
BPI-2009H icotinib    
CI-1033, PD183805 canertinib    
CO-1686 rociletinib   wild type-sparing EGFR inhibitor
EGF816     wild type-sparing EGFR inhibitor
HM61713     wild type-sparing EGFR inhibitor
HMPL-813 epitinib    
MNPL-309 theliatinib    
OSI-774, CP-258,774 erlotinib Tarceva  
XL647, KD019      
ZD1839 gefitinib Iressa  
EGFR (HER1/ERBB1)
HER2 (ERBB2/neu)
HER3 (ERBB3)
AZD8931      
EGFR (HER1/ERBB1)
HER2 (ERBB2/neu)
HER4 (ERBB4)
BMS-599626, AC480      
BMS-690514, EVRI      
EKB-569 pelitinib    
HM781-36B poziotinib    
PF-00299804 dacomitinib    
EphB4 MGCD516      
XL647, KD019      
FAK AB1010 masitinib Masivet  
GSK2256098      
VS-4718      
VS-6063 defactinib    
FGFR1/2/3 AB1010 masitinib Masivet  
AP24534 ponatinib Iclusig  
AZD4547      
BGJ398, NVP-BGJ398      
BIBF1120 nintedanib Vargatef  
Debio 1347, CH5183284      
E-3810 lucitanib    
HMPL-012 sulfatinib    
LY2874455      
TKI258, CHIR-258 dovitinib    
XL228    
FGFR1/2/3/4 JNJ-42756493      
FGFR1 TSU 68, SU6668 orantinib    
FGFR3 ENMD-2076      
FLT3 AC220 quizartinib    
AP24534 ponatinib Iclusig  
AS703569, R763 cenisertib    
ASP2215 gilteritinib    
BAY 43-9006 sorafenib Nexavar  
CEP-701 lestaurtinib    
CP-868569 crenolanib    
ENMD-0276      
MLN518, CT53518 tandutinib    
MP-470 amuvatinib    
PKC412 midostaurin    
PLX3397, PLX108-01      
SU-11248 sunitinib Sutent  
XL184 cabozantinib Cometriq  
HER2 (ERBB2/neu) AEE788, NVP-AEE788      
ARRY 380      
BIBW-2992 afatinib Gilotrif, Tomtovok  
CI-1033, PD183805 canertinib    
GSK572016, GW2016, GW-572016 lapatinib Tykerb  
HKI-272 neratinib    
TAK 165 mubritinib    
XL647, KD019      
IGF 1/2 MEDI-573 dusigitumab    
HGFR MGCD516      
IGF-1R BMS-536924      
BMS-754807      
OSI-906 ​linsitinib    
XL228    
JAK1 PRT062070      
JAK1/2 AZD1480      
CYT-387, CYT387 momelotinib    
INCB018424 ruxolitinib Jakafi  
JAK2 AT9283      
BMS-911543      
CEP-701 lestaurtinib    
SAR302503, TG101348 fedratinib    
SB1518 pacritinib    
XL019      
JAK2 V617F SB1518 pacritinib    
LY2784544 gandotinib    
XL019      
JAK3 CP-690550 tofacitinib citrate Xeljanz  
PRT062070      
KIT AB1010 masitinib Masivet  
AG-013736 axitinib Inlyta  
AMG706 motesanib    
AS703569, R763 cenisertib    
BAY 57-9352 telatinib    
BAY 73-4506 regorafenib Stivarga  
BMS-354825 dasatinib Sprycel  
GW786034 pazopanib Votrient  
MGCD516      
MLN518, CT53518 tandutinib    
MP-470 amuvatinib    
PKC412 midostaurin    
PLX3397, PLX108-01      
STI-571, CGP57148, CGP57148B imatinib Gleevec  
SU-11248 sunitinib Sutent  
XL184 cabozantinib Cometriq  
XL820      
LYN INNO-406, NS-187 bafetinib    
AS703569, R763 cenisertib    
MAPK1 (ERK) BVD-523      
LY2228820 ralimetinib    
MK-8353, SCH900353      
MEK AS703026, MSC1936369B pimasertib    
AZD6244, ARRY-142886 selumetinib    
AZD8330      
BAY 86-9766, RDEA119 refametinib    
BI 847325      
CI-1040      
GDC-0623      
GDC-0973 cobimetinib    
GSK1120212 trametinib Mekinist  
MEK162 binimetinib    
PD0325901, PD-0325901      
RO5126766, CH5126766      
TAK-733      
MET AMG 208      
AMG 337      
ARQ 197 tivantinib    
BMS-777607      
EMD 1214063, MSC2156119J      
EXEL-2880, GSK1363089, XL880 foretinib    
HMPL-504 volitinib    
INCB028060, INC280      
MGCD265      
MGCD516      
MK-2461      
MP-470 amuvatinib    
PF-02341066 crizotinib Xalkori  
PF-04217903      
SAR125844      
XL184 cabozantinib Cometriq  
MST1R MGCD265      
mTOR AP23573, MK8669 ridaforolimus (deforolimus)   rapalogue​
AY 22989, SILA 9268A, WY-090217 sirolimus Rapamune rapalogue​​
AZD2014      
AZD8055     TORC1/2, catalytic inhibitor​
BEZ235, NVP-BEZ235 dactolisib   catalytic, dual PI3K/mTOR inhibitor
BGT226, NVP-BGT226     dual PI3K/mTOR inhibitor
CC-223      
CCI-779 temsirolimus Torisel rapalogue​
GDC-0980 apitolisib   catalytic, dual PI3K/mTOR inhibitor
MLN0128, INK128     TORC1/2, catalytic inhibitor​
OSI-027     TORC1/2, catalytic inhibitor​
PF-4691502     catalytic, dual PI3K/mTOR inhibitor
PI-103     catalytic, dual PI3K/mTOR inhibitor
PKI-587, PF-05212384 gedatolisib   pan-PI3K inhibitor, catalytic, dual PI3K/mTOR inhibitor
PWT33597     catalytic, dual PI3K/mTOR inhibitor
RAD001 everolimus Afinitor rapalogue​
SF1126     catalytic, dual PI3K/mTOR inhibitor
XL765, SAR245409 voxtalisib   catalytic, dual PI3K/mTOR inhibitor
NTRK1/2/3
(TRKA/B/C)
AZD7451      
LOXO-101      
MGCD516      
PLX7486      
RXDX-101      
TSR-011      
NTRK1 (TRKA) CEP-701 lestaurtinib    
PDGFR ABT-348 ilorasertib    
AMG706 motesanib    
BIBF1120 nintedanib Vargatef  
GW786034 pazopanib Votrient  
MGCD516      
MLN518, CT53518 tandutinib    
STI-571, CGP57148, CGP57148B imatinib Gleevec  
X-82     inhibits all isoforms
PDGFRα CP-868569 crenolanib    
MP-470 amuvatinib    
PKC412 midostaurin    
PDGFRβ ABT-869 linifanib    
AG-013736 axitinib Inlyta  
BAY 43-9006 sorafenib Nexavar  
BAY 57-9352 telatinib    
BAY 73-4506 regorafenib Stivarga  
SU-11248 sunitinib Sutent  
TSU 68, SU6668 orantinib    
XL820      
PI3K BAY 80-6946 copanlisib   pan-PI3K inhibitor
BEZ235, NVP-BEZ235 dactolisib   catalytic, dual PI3K/mTOR inhibitor
BGT226, NVP-BGT226     dual PI3K/mTOR inhibitor
BKM120 buparlisib   pan-PI3K inhibitor
BYL719      
GDC-0941 pictilisib   pan-PI3K inhibitor
GDC-0980 apitolisib   catalytic, dual PI3K/mTOR inhibitor
GSK2126458 omipalisib   pan-PI3K inhibitor
GSK2636771      
PF-4691502     catalytic, dual PI3K/mTOR inhibitor
PI-103     catalytic, dual PI3K/mTOR inhibitor
PKI-587, PF-05212384 gedatolisib   pan-PI3K inhibitor, catalytic
PWT33597     catalytic, dual PI3K/mTOR inhibitor
PX-866      
SF1126     catalytic, dual PI3K/mTOR inhibitor
XL147, SAR245408 pilaralisib   pan-PI3K inhibitor
XL765, SAR245409 voxtalisib   catalytic, ​dual PI3K/mTOR inhibitor
  sophoretin, quercetin    
PI3Kα BYL719      
GDC-0032 taselisib    
INK-1117      
PI3Kδ CAL-101, GS-1101 idelalisib Zydelig  
TGR-1202      
PI3Kδ/γ IPI-145, INK-1197 duvelisib    
PKC   sophoretin, quercetin    
PKCα LY317615 enzastaurin    
PKC412 midostaurin    
PKCβ LY317615 enzastaurin    
PKCγ LY317615 enzastaurin    
PKCε LY317615 enzastaurin    
PLK1 BI 6727 volasertib    
BI 2536      
GSK461364, GSK-461364      
NMS-1286937      
ON 01910.Na rigosertib Estybon  
RAF BAY 43-9006 sorafenib Nexavar  
BAY 73-4506 regorafenib Stivarga  
LGX818 encorafenib    
MLN2480      
RO5126766, CH5126766      
XL281, BMS-908662      
RET AMG706 motesanib    
AZD6474, ZD6474 vandetanib Zactima, Caprelsa  
BAY 43-9006 sorafenib Nexavar  
BAY 73-4506 regorafenib Stivarga  
MGCD516      
MP-470 amuvatinib    
SU-11248 sunitinib Sutent  
XL184 cabozantinib Cometriq  
ROS1 PF-02341066 crizotinib Xalkori  
PF-06463922      
RXDX-101      
RPS6KB1 (p70S6K) AT13148      
SCFR AB1010 masitinib Masivet  
MGCD516      
SRC AZD0530 saracatinib    
ABT-348 ilorasertib    
BMS-354825 dasatinib Sprycel  
KX2-391      
XL228    
SYK PRT062070      
R788 fostamatinib​    
TBK1 CYT-387, CYT387 momelotinib    
TEK MGCD265      
XL184 cabozantinib Cometriq  
TGFBR1 LY2157299 galunisertib    
TEW-7197      
TORC1/2 AZD8055     catalytic inhibitor​
MLN0128, INK128     catalytic inhibitor​
OSI-027     catalytic inhibitor​
VEGFR ABT-869 linifanib    
ENMD-2076      
EXEL-2880, GSK1363089, XL880 foretinib    
HMPL-012 sulfatinib    
PTK 787, CGP 79787, ZK 222584 vatalanib    
TSU 68, SU6668 orantinib    
X-82     inhibits all isoforms
XL647, KD019      
VEGFR1/2/3 ABT-348 ilorasertib    
AG-013736 axitinib Inlyta  
AMG706 motesanib    
BAY 73-4506 regorafenib Stivarga  
BIBF1120 nintedanib Vargatef  
E-3810 lucitanib    
GW786034 pazopanib Votrient  
HMPL-013 fruquintinib    
KRN951, AV-951 tivozanib    
MGCD265      
MGCD516      
VEGFR2 AEE788, NVP-AEE788      
AP24534 ponatinib Iclusig  
AZD2171 cediranib    
AZD6474, ZD6474 vandetanib Zactima, Caprelsa  
BAY 43-9006 sorafenib Nexavar  
BMS-582664 brivanib    
BMS-690514, EVRI      
DP-1919.TO, DCC-2036 rebastinib tosylate    
E7080 lenvatinib Lenvima  
PKC412 midostaurin    
RAF265      
SU-11248 sunitinib Sutent  
XL184 cabozantinib Cometriq  
XL820      
YN968D1 apatinib    
VEGFR2/3 BAY 57-9352 telatinib    
WEE1 AZD1775, MK1775      

Therapeutic Antibodies
Target Development Name(s) Generic Name(s) Trade
Name(s)
Notes
ANGPT1/2 (ANG1/2) AMG 780      
ANGPT2 (ANG2) MEDI-3617      
REGN910 nesvacumab    
RO5520985, RG7221      
BAFF   belimumab Benlysta  
CCR4 KW-0761 mogamulizumab    
B4GALNT1 Ch14.18, ch14.18-UTC dinutuximab    
CD19 MEDI-551        
CD19/CD3 MT103, MT-103, MEDI-538 blinatumomab Blincyto  
CD20 GA101 obinutuzumab Gazyvaro  
IDEC-102, IDEC-C2B8 rituximab Rituxan, Mabthera  
IDEC Y2B8 ibritumomab tiuxetan Zevalin drug can be bound via tiuxetan to 111In or 90Y
  ofatumumab Arzerra, HuMax-CD20  
  tositumomab Bexxar drug can be bound with or without 131iodine
CD22 CAT-8015 moxetumomab pasudotox    
CD27 CDX-1127 varlilumab    
CD33   gemtuzumab Mylotarg  
CD37 TRU-016 otlertuzumab    
CD38   daratumumab HuMax-CD38  
SAR650984      
CD52 Campath alemtuzumab    
CD70 ARGX-110      
SGN-70, h1F6 vorsetuzumab    
CD74 hLL1 milatuzumab    
CD105 TRC105      
CD248 (TEM1) MORAb-004 ontuxizumab    
CTLA4 CP675,206 tremelimumab    
MDX-010, MDX-101, BMS-734016 ipilimumab Yervoy  
DLL4 OMP-21M18 demcizumab    
EGFL7 MEGF0444A parsatuzumab    
EGFR (HER1/ERBB1) ABT-806, mAb-806      
ABX-EGF panitumumab Vectibix  
h-R3, TheraCIM nimotuzumab    
IMC-11F8 necitumumab    
IMC-C225 cetuximab Erbitux  
MEHD7945 A duligotuzumab    
MM-151      
RO5083945, GA201 imgatuzumab    
Sym004 futuximab    
FZD7 OMP-18R5 vantictumab    
HER2 (ERBB2/neu) GT-Mab 7.3-GEX glycooptimized trastuzumab-GEX     
MGAH22 margetuximab    
MM-111      
MOAB 2C4 pertuzumab Perjeta, Omnitarg  
  trastuzumab Herceptin  
HER3 (ERBB3) AV 203      
LJM716      
MEHD7945 A duligotuzumab    
MM-111      
MM-121, SAR256212 seribantumab    
MM-141      
REGN1400      
U3-1287, AMG 888 patritumab    
HGFR AMG 102 rilotumumab    
AV-299, SCH900105 ficlatuzumab    
IGF-1R AMG-479 ganitumab    
BI 836845      
BIIB022      
CP-751871 figitumumab    
IMC-A12 cixutumumab    
MEDI-573      
MK-0646 dalotuzumab    
MM-141      
IGF-2R BI 836845      
MEDI-573      
KIR BMS-986015 lirilumab    
LOXL2 AB0024, GS-6624 simtuzumab    
MET ABT-700      
LY2875358 emibetuzumab    
MetMAb, R05490258, OA-5D onartuzumab    
MMP9 GS-5745      
NRP1 MNRP1685A vesencumab    
PD-1 AMP-224      
BMS-936558, MDX-1106, ONO-4538 nivolumab Opdivo  
CT-011 pidilizumab    
MK-3475, lambrolizumab pembrolizumab Keytruda  
PD-L1 MDX-1105, BMS-936559      
MEDI-4736 durvalumab    
MPDL3280A, RG7446 atezolizumab    
MSB0010718C      
PDGFRα IMC-3G3 olaratumab    
MEDI-575 tovetumab    
PIGF   ziv-aflibercept Zaltrap  
RANKL   denosumab Xgeva  
SEMA4D VX15/2503      
TGFBR2 IMC-TR1      
TNFRSF9 (CD137/4-1BB) BMS 663513 urelumab    
PF-05082566      
TRAIL-R1/DR4,R2/D5 AMG951, rhApo2L/TRAIL dulanermin    
TRAIL-R1/D4 HGS-ETR1 mapatumumab    
TRAIL-R2/D5 AMG-655 conatumumab    
HGS-ETR2 lexatumumab    
LBY135      
PRO95780 apomab    
VEGFA   bevacizumab Avastin  
RO5520985, RG7221      
  ziv-aflibercept Zaltrap  
VEGFB   ziv-aflibercept Zaltrap  
VEGFC VGX-100      
VEGFR2 IMC-1121B ramucirumab Cyramza  

Antibody-Drug Conjugates
Target Drug conjugate Development Name(s) Generic Name(s) Trade
Name(s)
Notes
CD19 maytansinoid DM4 SAR3419      
CD22 calicheamycin CMC-544 inotuzumab ozogamicin    
monomethyl auristatin E RG7593, DCDT2980S pinatuzumab vedotin    
CD30 monomethyl auristatin E SGN-35 brentuximab vedotin Adcetris  
CD33 calicheamycin   gemtuzumab ozogamicin Mylotarg  
CD56 maytansinoid DM1 IMGN-901 lorvotuzumab mertansine    
CD70 Prodrug of duocarmycin analogue BMS-936561, MDX-1203      
monomethyl auristatin F SGN-75 vorsetuzumab mafodotin    
CD79b monomethyl auristatin E RG7596, DCDS4501A polatuzumab vedotin    
CEACAM5 SN-38 IMMU-130      
EGFR monomethyl auristatin F ABT414      
EGFRvIII maytansinoid DM1 AMG 595      
FOLH1 (PSMA) monomethyl auristatin E PSMA ADC      
FOLR1 maytansinoid DM4 IMGN853      
GPNMB monomethyl auristatin E CDX-011 glembatumumab vedotin    
GUCY2C (GCC) monomethyl auristatin E MLN0264      
HER2 (ERBB2/neu) maytansinoid DM1 PRO132365 ado trastuzumab emtansine Kadcyla  
Mesothelin Monomethyl auristatin E DMOT4039A      
MUC16 protein (CA-125) Monomethyl auristatin E Anti-MUC16 ADC, DMUC5754A sofituzumab vedotin    
Nectin-4 Monomethyl auristatin E AGS-22M6E enfortumab vedotin    
SLC34A2 (NaPi2b) monomethyl auristatin E DNIB0600A, RG7599 lifastuzumab vedotin    
STEAP1 monomethyl auristatin E DSTP3086S, RG7450      
TACSTD2 (TROP2) SN-38 IMMU-132      

Immunotherapies
Target Development Name(s) Generic Name(s) Trade
Name(s)
Notes
CD19 CTL019, CART19 tisagenlecleucel-T    
CD227 (MUC1) BLP25 tecemotide    
IMMU-107, hPAM4, IgG-DOTA clivatuzumab tetraxetan    
CTLA4 CP675,206 tremelimumab    
MDX-010, MDX-101, BMS-734016 ipilimumab Yervoy  
IDO1 INCB024360      
NLG-919      
IL-6   siltuximab Sylvant  
IL-6R R-1569 tocilizumab Actemra  
IL-1β ACZ885 canakinumab Ilaris  
KIR BMS-986015 lirilumab    
PD-1 AMP-224      
BMS-936558, MDX-1106, ONO-4538 nivolumab Opdivo  
CT-011 pidilizumab    
MK-3475, lambrolizumab pembrolizumab Keytruda  
PD-L1 MDX-1105, BMS-936559      
MEDI-4736 durvalumab    
MPDL3280A, RG7446 atezolizumab    
MSB0010718C      
SEMA4D VX15/2503      
TNFRSF9 (CD137/4-1BB) BMS 663513 urelumab    
PF-05082566      
Other Ad.p53 DC vaccine     cancer vaccine
AGS-003     cancer vaccine
APC8015 sipuleucel-T Provenge cancer vaccine
BPX-201     cancer vaccine
CDX-1401      
CG8123, GVAX     cancer vaccine
DC-TC eltrapuldencel-T    
DCVAC/Pca     cancer vaccine
E75 Peptide nelipepimut-S    
ETBX-011     cancer vaccine
GI-6301     cancer vaccine
HyperAcute-Lung, HAL tergenpumatucel-L    
HS-110 viagenpumatucel-L   cancer vaccine
HS-410 vesigenurtacel-L   cancer vaccine
IMA901     cancer vaccine
MAGE-A3     cancer vaccine
NLG-12036, HyperAcute-Melanoma dorgenmeltucel-L   cancer vaccine
OncoVex GM-CSF, T-VEC taliminogene laherparepvec   cancer vaccine
ONT-10     cancer vaccine
polyvalent melanoma vaccine, PMCV     cancer vaccine
Prostvac-V rilimogene galvacirepvec    
PSA/IL-2/GM-CSF vaccine     cancer vaccine
TG4010, MVA-MUC1-IL2     cancer vaccine
TheraCys BCG vaccine   cancer vaccine
TSF aldesleukin Proleukin  
VGX-3100     cancer vaccine
  belagenpumatucel-L Lucanix cancer vaccine
  enadenotucirev    
  interferon alpha-2b Intron A  
  peginterferon alfa-2b PEG-Intron  

Chemotherapies
Type of Chemotherapy Subtype Generic Name(s) Trade
Name(s)
Notes
Alkylating Agents Alkyl sulfonates busulfan Busulfex, Myleran  
Ethylenimines thiotepa Girostan  
Nitrogen mustard bendamustine Treanda, Ribomustin  
chlorambucil Leukeran  
cyclophosphamide Cytoxan  
ifosfamide Ifex  
melphalan Alkeran  
palifosfamide tris    
Nitrosoureas carmustine BiCNU, Gliadel  
lomustine CeeNU  
streptozocin Zanosar  
Platinum analogues carboplatin Paraplatin  
cisplatin Platinol  
oxaliplatin Eloxatin  
Triazenes dacarbazine DTIC-Dome  
temozolomide Temodar  
Other procarbazine Matulane  
Antimetabolites Folate antagonists methotrexate Abitrexate  
pemetrexed Alimta  
pralatrexate Folotyn  
raltitrexed Tomudex  
Purine analogues cladribine Leustatin  
clofarabine Clolar  
fludarabine Fludara  
mercaptopurine Purinethol  
nelarabine Arranon  
pentostatin Nipent  
thioguanine Tabloid  
Pyrimidine analogues capecitabine Xeloda  
cytarabine Cytosar-U  
floxuridine FUDR  
fluorouracil Adrucil  
gemcitabine Gemzar  
Other hydroxyurea Droxia, Hydrea  
Antimicrotubule Agents Epothilones ixabepilone Ixempra  
Halichondrin B analogue eribulin mesylate Halaven  
Taxanes paclitaxel Taxol  
albumin-bound paclitaxel, nab-paclitaxel Abraxane  
docetaxel Taxotere  
cabazitaxel Jevtana  
Vinca alkaloids vinblastine Velban, Velsar  
vincristine Vincasar PFS  
liposomal vincristine Marqibo  
vinorelbine Navelbine  
Protein synthesis inhibitors Cephalotaxine omacetaxine mepesuccinate Synribo  
Topoisomerase I inhibitors Camptothecin derivatives etirinotecan pegol    
irinotecan Camptosar  
topotecan Hycamptin  
Quinoline alkaloids camptothecin    
Topoisomerase II inhibitors Anthracenedione mitoxantrone Novantrone  
Anthracyclines daunorubicin Cerubidine  
liposomal daunorubicin DaunoXome  
doxorubicin Adriamycin PFS  
liposomal doxorubicin Doxil  
epirubicin Ellence  
idarubicin Idamycin  
valrubicin Valstar  
Epipodophyllotoxins etoposide/etoposide phosphate Toposar, Etopophos  
teniposide Vumon  
Other amonafide    
Other Antitumor antibiotic bleomycin Blenoxane  
dactinomycin Cosmegen  
mitomycin Mutamycin  
Aspariginase derivatives e. coli derived asparaginase Elspar  
erwinia derived asparaginase Erwinaze  
pegaspargase Oncaspar  
Hypomethylating Agents azacitidine Vidaza  
decitabine Dacogen  
Retinoic acid derivatives alitretinoin Panretin  
bexarotene Targretin  
isotretinoin Accutane  
tretinoin ATRA  
Telomerase template antagonist imetelstat    
Other arsenic trioxide Trisenox  
mitotane Lysodren  
trabectedin Yondelis  
denileukin diftitox Ontak  
lanreotide Somatuline Depot Injection  
octreotide Sandostatin, Sandostatin LAR  
dexamethasone/prednisone Decadron  

Hormonal Agents
Type of Agent Development Name Generic Name(s) Trade
Name(s)
Notes
Selective androgen receptor modulator (SARM) GTX-024 enobosarm Osterine  
Androgen receptor antagonist   nilutamide Nilandron, Anandron  
  bicalutamide Casodex  
  flutamide Eulexin, Apimid  
MDV3100 enzalutamide Xtandi  
Aromatase inhibitor CGS 20267 letrozole Femara  
FCE-24304 exemestane Aromasin  
  anastrozole Arimidex  
Estrogen receptor antagonist   fulvestrant Faslodex  
Selective estrogen receptor modulator (SERM)   tamoxifen Nolvadex, Soltamox  
LY-139481 raloxifene Evista, Keoxifene  
  toremifene Fareston  
Selective estrogen receptor degrader (SERD) ARN-810      
LH-RH analogues and antagonists   degarelix Firmagon  
  leuprolide Lupron  
  triptorelin Trelstar  
  goserelin Zoladex  
Other   abiraterone Zytiga  
  megestrol acetate Megace  
  estramustine Emcyt, Estracyt  
  ketoconazole    

Other
Target Development Name(s) Generic Name(s) Trade
Name(s)
Notes
ADORA3 (A3AR) CF102      
ANGPT1/2 (ANG1/2) AMG 386 trebananib    
Arginine ADI-PEG 20 pegargiminase    
Bcl-2 ABT-263, ABT-737 navitoclax    
AT101      
GDC-0199, ABT-0199, ABT-199, RG7601 venetoclax    
GX15-070 obatoclax    
G3139 oblimerson Genasense  
BRD2/3/4 OTX015      
CPAA NEO-102, NPC-IC ensituximab    
CXCR4 BMS-936564, MDX-1338 ulocuplumab    
LY2510924      
Cyclin D ON 014185, ON 01305 briciclib    
ON 013105 briciclib sodium    
DOT1L EPZ-5676      
EC1456       Small molecule-drug conjugate
endo-Beta-D-glucuronidase heparanase PI-88 muparfostat    
EZH2 EPZ-6438, E7438      
Farnesyl protein transferase (FTase) IND 58359 tipifarnib Zarnestra  
FGF 1/2 PI-88 muparfostat    
FGFR1 HGS1036, FP-1039, GSK3052230      
Folate receptor EC145 vintafolide   folate-vinca alkaloid conjugate
Gamma-secretase MK0752    
FOLH1 (PMSA) G-202 mipsagargin    
FZD8 OMP-54F28 ipafricept    
HDAC 4SC-201 resminostat    
CRA-024781, PCI-24781 abexinostat    
FK228 romidepsin Istodax  
LBH589 panobinostat Farydak, Faridak  
MGCD0103 mocetinostat    
MK-0683 vorinostat Zolinza  
MS-275, SNDX-275 entinostat    
PXD101 belinostat Beleodaq  
HDAC6 ACY-1215, ACY-63 ricolinostat    
HDM2/P53 SAR405838, MI-773      
HSP27 OGX-427 apatorsen    
Hedgehog PF-04449913 glasdegib    
HSP90 17-AAG, KOS-953 tanespimycin    
AT13387 onalespib    
AUY922 luminespib    
Debio 0932      
IPI-504 retaspimycin    
SNX-5422      
STA-9090 ganetespib    
XL888      
Inhibitor of Apoptosis Protein (IAP) TL32711 birinapant    
IDH1 AG-120      
IDO 1-methyl-d-tryptophan indoximod    
KDM1A (LSD1) GSK2879552      
KIF11 (KSP/EG5) ARRY-520 filanesib    
4SC-205      
MDM2 RG7388, RO5503781      
Mesothelin MORAB-009 amatuximab    
Microtubule BAL101553      
Nedd8 Activating Enzyme (NAE) MLN4924 pevonedistat    
Notch Pathway MK0752      
OMP-59R5 tarextumab    
PF-03084014      
REGN421      
RO4929097, R4733      
PARP ABT-888 veliparib    
AG-014699, PF-01367338 rucaparib    
AZD2281 olaparib Lynparza  
BMN 673 talazoparib    
BSI-201 iniparib    
MK4827 niraparib    
Phosphotidylserine   bavituximab    
PMSA BIND-014      
PORCN LGK974      
PP2A LB-100      
PPAR-γ CS 7017, RS5444      
Proteasome LDP 341, MLN341, PS-341 bortezomib Velcade  
PR-171 carfilzomib Kyprolis  
PTCH GDC-0449 vismodegib Erivedge  
Smoothened GDC-0449 vismodegib Erivedge  
IPI-926, sandegib patidegib    
LDE225, erismodegib sonidegib Odomzo  
LY2940680 taladegib    
STAT3 OPB-31121      
TLR8 VTX-2337, VTX-378 motolimod    
TLR5 CBLB502 entolimod    
VEGF PI-88 muparfostat    
XPO1 (CRM1) KPT-330 selinexor    
Other BBI503      
BBI608      
CC-4047 pomalidomide Pomalyst thalidomide derivative
CC-5013 lenalidomide Revlimid thalidomide analog
  thalidomide Thalomid  
M402 necuparanib    
NHS-IL12      
PRX302 topsalysin    
TH-302 evofosfamide    
VAL-083, NSC-1323313 dianhydrogalactitol    

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Contributors: Jonathan L. Aston, Pharm.D., Christine M. Lovly, M.D., Ph.D.

Suggested Citation: Aston, J., C. Lovly. 2015. Anticancer Agents. My Cancer Genome http://www.mycancergenome.org/content/molecular-medicine/anticancer-agents/ (Updated August 28).

Last Updated: August 28, 2015

Disclaimer: The information presented at MyCancerGenome.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.