Targeted Therapeutics
| Kinase Inhibitors | ||||
|---|---|---|---|---|
| Target | Development Name(s) | Generic Name(s) | Trade Name(s) |
Notes |
| ABL | AMN107 | nilotinib | Tasigna | |
| AP24534 | ponatinib | Iclusig | ||
| AS703569, R763 | cenisertib | |||
| AT9283 | ||||
| BMS-354825 | dasatinib | Sprycel | ||
| INNO-406, NS-187 | bafetinib | |||
| SKI-606 | bosutinib | Bosulif | ||
| STI-571, CGP57148, CGP57148B | imatinib | Gleevec | ||
| XL228 | | |||
| AKT | AS703569, R763 | cenisertib | catalytic inhibitor | |
| AZD5363 | catalytic inhibitor | |||
| GDC-0068 |
catalytic inhibitor |
|||
| MK-2206 | allosteric inhibitor | |||
| ALK (Anaplastic Lymphoma Kinase) |
AP26113 | |||
| ASP3026 | ||||
| CH5424802, AF802 |
|
|||
| LDK378 | ||||
| PF-02341066 | crizotinib | Xalkori | ||
| TSR-011 | ||||
| X-396 | ||||
| Aurora A | AS703569, R763 | cenisertib | ||
| AT9283 | ||||
| ENMD-2076 | ||||
| MK5108 | ||||
| MLN8237 | alisertib | |||
| PF-03814735 | ||||
| TAK901 | ||||
| Aurora B | AS703569, R763 | cenisertib | ||
| AT9283 | ||||
| AZD1152-HQPA, AZD1152 | barasertib |
|||
| GSK1070916 | ||||
| PF-03814735 | ||||
| Aurora C | GSK1070916 | |||
| Aurora A/B/C | AMG900 | |||
| BI 847325 | ||||
| PHA-739358 | danusertib | |||
| SNS-314 | ||||
| BRAF | ARQ 736 | |||
| GSK2118436 | dabrafenib | |||
| PLX-4032, RG7204, R05185426 | vemurafenib | Zelboraf | ||
| RAF265 | ||||
| RO5212054, PLX3603 | ||||
| BTK | AS703569, R763 | cenisertib | ||
| PCI-32765 | ibrutinib | |||
| CDK 1,2,4,5,6,7,9 (pan-CDK) | HMR-1275, L868275, flavopiridol | alvocidib | ||
| CDK 1,2,5,9 | SCH727965 | dinaciclib | ||
| CDK 2,7,9 | CYC202 | seliciclib | ||
| CDK 4,6 | LEE011 | |||
| LY2835219 | ||||
| PD 0332991 | palbociclib | |||
| CSF-1R | PLX3397, PLX108-01 | |||
| EGFR (HER1/ERBB1) | AEE788, NVP-AEE788 | |||
| AP26113 | ||||
| AZD6474, ZD6474 | vandetanib | Zactima, Caprelsa | ||
| BIBW-2992 | afatinib | Tomtovok | ||
| BPI-2009H | icotinib | |||
| CI-1033, PD183805 | canertinib | |||
| CO-1686 | ||||
| HMPL-813 | epitinib |
|||
| MNPL-309 | theliatinib | |||
| OSI-774, CP-258,774 | erlotinib | Tarceva | ||
| XL647, KD019 | ||||
| ZD1839 | gefitinib | Iressa | ||
| EGFR (HER1/ERBB1) HER2 (ERBB2/neu) HER3 (ERBB3) |
AZD8931 | |||
| EGFR (HER1/ERBB1) HER2 (ERBB2/neu) HER4 (ERBB4) |
BMS-599626, AC480 | |||
| BMS-690514, EVRI | ||||
| EKB-569 | pelitinib | |||
| PF-00299804 | dacomitinib | |||
| EphB4 | XL647, KD019 | |||
| FAK | AB1010 | masitinib | Masivet | |
| FGFR1/2/3 | AB1010 | masitinib | Masivet | |
| AP24534 | ponatinib | Iclusig | ||
| AZD4547 | ||||
| BGJ398, NVP-BGJ398 | ||||
| BIBF1120 | nintedanib | Vargatef | ||
| E-3810 | ||||
| HMPL-012 | sulfatinib | |||
| TKI258, CHIR-258 | dovitinib | |||
| XL228 | | |||
| FGFR1 | TSU 68, SU6668 | orantinib | ||
| FGFR3 | ENMD-2076 | |||
| FLT3 | AC220 | quizartinib | ||
| AP24534 | ponatinib | Iclusig | ||
| AS703569, R763 | cenisertib | |||
| CEP-701 | lestaurtinib | |||
| ENMD-0276 | ||||
| MLN518, CT53518 | tandutinib | |||
| MP-470 | amuvatinib | |||
| PKC412 | midostaurin | |||
| PLX3397, PLX108-01 | ||||
| SU-11248 | sunitinib | Sutent | ||
| XL184 | cabozantinib | Cometriq | ||
| HER2 (ERBB2/neu) | AEE788, NVP-AEE788 | |||
| ARRY 380 | ||||
| BIBW-2992 | afatinib | Tomtovok | ||
| CI-1033, PD183805 | canertinib | |||
| GSK572016, GW2016, GW-572016 | lapatinib | Tykerb | ||
| HKI-272 | neratinib | |||
| TAK 165 | mubritinib | |||
| XL647, KD019 | ||||
| IGF-1R | BMS-536924 | |||
| BMS-754807 | ||||
| OSI-906 | linsitinib | |||
| XL228 | | |||
| JAK1/2 | AZD1480 | |||
| CYT-387 | momelotinib | |||
| INCB18424 | ruxolitinib | Jakafi | ||
| JAK2 | AT9283 | |||
| BMS-911543 | ||||
| CEP-701 | lestaurtinib | |||
| SAR302503, TG101348 | ||||
| SB1518 | pacritinib | |||
| XL019 | ||||
| JAK2 V617F | SB1518 | pacritinib | ||
| LY2784544 | ||||
| XL019 | ||||
| JAK3 | CP-690550 | tofacitinib citrate | Xeljanz | |
| KIT | AB1010 | masitinib | Masivet | |
| AG-013736 | axitinib | Inlyta | ||
| AMG706 | motesanib | |||
| AS703569, R763 | cenisertib | |||
| BAY 57-9352 | telatinib | |||
| BAY 73-4506 | regorafenib | Stivarga | ||
| BMS-354825 | dasatinib | Sprycel | ||
| GW786034 | pazopanib | Votrient | ||
| MLN518, CT53518 | tandutinib | |||
| MP-470 | amuvatinib | |||
| PKC412 | midostaurin | |||
| PLX3397, PLX108-01 | ||||
| STI-571, CGP57148, CGP57148B | imatinib | Gleevec | ||
| SU-11248 | sunitinib | Sutent | ||
| XL184 | cabozantinib | Cometriq | ||
| XL820 | ||||
| LYN | INNO-406, NS-187 | bafetinib | ||
| AS703569, R763 | cenisertib | |||
| MEK | AS703026, MSC1936369B | pimasertib | ||
| AZD6244, ARRY-142886 | selumetinib | |||
| AZD8330 | ||||
| BAY 86-9766, RDEA119 | refametinib | |||
| BI 847325 | ||||
| CI-1040 | ||||
| GDC-0623 | ||||
| GDC-0973 | ||||
| GSK1120212 | trametinib | |||
| MEK162 | ||||
| PD0325901, PD-0325901 | ||||
| TAK-733 | ||||
| MET | AMG 208 | |||
| ARQ 197 | tivantinib | |||
| BMS-777607 | ||||
| EMD 1214063 | ||||
| EXEL-2880, GSK1363089, XL880 | foretinib | |||
| HMPL-504 | volitinib | |||
| INCB028060, INC280 | ||||
| MGCD265 | ||||
| MK-2461 | ||||
| MP-470 | amuvatinib | |||
| PF-02341066 | crizotinib | Xalkori | ||
| PF-04217903 | ||||
| XL184 | cabozantinib | Cometriq | ||
| mTOR | AP23573, MK8669 | ridaforolimus (deforolimus) | rapalogue | |
| AY 22989, SILA 9268A, WY-090217 | sirolimus | Rapamune |
rapalogue |
|
| AZD8055 | TORC1/2, catalytic inhibitor |
|||
| BEZ235, NVP-BEZ235 | catalytic, dual PI3K/mTOR inhibitor | |||
| BGT226, NVP-BGT226 | dual PI3K/mTOR inhibitor | |||
| CCI-779 | temsirolimus | Torisel |
rapalogue |
|
| GDC-0980 | catalytic, dual PI3K/mTOR inhibitor | |||
| MLN0128, INK128 | TORC1/2, catalytic inhibitor |
|||
| OSI-027 | TORC1/2, catalytic inhibitor |
|||
| PF-4691502 | catalytic, dual PI3K/mTOR inhibitor | |||
| PI-103 | catalytic, dual PI3K/mTOR inhibitor | |||
| PKI-587 | pan-PI3K inhibitor, catalytic, dual PI3K/mTOR inhibitor |
|||
| PWT33597 | catalytic, dual PI3K/mTOR inhibitor | |||
| RAD001 | everolimus | Afinitor |
rapalogue |
|
| SF1126 | catalytic, dual PI3K/mTOR inhibitor | |||
| XL-765 | catalytic, dual PI3K/mTOR inhibitor | |||
| PDGFR | AMG706 | motesanib | ||
| BIBF1120 | nintedanib | Vargatef | ||
| GW786034 | pazopanib | Votrient | ||
| MLN518, CT53518 | tandutinib | |||
| X-82 | inhibits all isoforms | |||
| PDGFRα | CP-868569 | crenolanib | ||
| MP-470 | amuvatinib | |||
| PKC412 | midostaurin | |||
| PDGFRβ | ABT-869 | linifanib | ||
| AG-013736 | axitinib | Inlyta | ||
| BAY 43-9006 | sorafenib | Nexavar | ||
| BAY 57-9352 | telatinib | |||
| BAY 73-4506 | regorafenib | Stivarga | ||
| SU-11248 | sunitinib | Sutent | ||
| TSU 68, SU6668 | orantinib | |||
| XL820 | ||||
| PI3K | BAY 80-6946 | pan-PI3K inhibitor | ||
| BEZ235, NVP-BEZ235 | catalytic, dual PI3K/mTOR inhibitor | |||
| BGT226, NVP-BGT226 | dual PI3K/mTOR inhibitor | |||
| BKM120 | pan-PI3K inhibitor | |||
| BYL719 | ||||
| GDC-0941 | pan-PI3K inhibitor | |||
| GDC-0980 | catalytic, dual PI3K/mTOR inhibitor | |||
| GSK2636771 | ||||
| PF-4691502 | catalytic, dual PI3K/mTOR inhibitor | |||
| PI-103 | catalytic, dual PI3K/mTOR inhibitor | |||
| PKI-587 | pan-PI3K inhibitor, catalytic |
|||
| PWT33597 | catalytic, dual PI3K/mTOR inhibitor | |||
| PX-866 | ||||
| SF1126 | catalytic, dual PI3K/mTOR inhibitor | |||
| XL147, SAR245408 | pan-PI3K inhibitor | |||
| XL-765 | catalytic, dual PI3K/mTOR inhibitor | |||
| sophoretin, quercetin | ||||
| PI3Kα | BYL719 | |||
| GDC-0032 | ||||
| INK-1117 | ||||
| PI3Kδ | CAL-101, GS-1101 | |||
| PKC | sophoretin, quercetin | |||
| PKCα | LY317615 | enzastaurin | ||
| PKC412 | midostaurin | |||
| PKCβ | LY317615 | enzastaurin | ||
| PKCγ | LY317615 | enzastaurin | ||
| PKCε | LY317615 | enzastaurin | ||
| PLK1 | BI 6727 | volasertib | ||
| BI 2536 | ||||
| GSK461364, GSK-461364 | ||||
| NMS-1286937 | ||||
| ON 01910.Na | rigosertib | Estybon | ||
| RAF | BAY 43-9006 | sorafenib | Nexavar | |
| BAY 73-4506 | regorafenib | Stivarga | ||
| LGX818 | ||||
| XL281, BMS-908662 | ||||
| RET | AMG706 | motesanib | ||
| AZD6474, ZD6474 | vandetanib | Zactima, Caprelsa | ||
| BAY 43-9006 | sorafenib | Nexavar | ||
| BAY 73-4506 | regorafenib | Stivarga | ||
| MP-470 | amuvatinib | |||
| SU-11248 | sunitinib | Sutent | ||
| XL184 | cabozantinib | Cometriq | ||
| ROS1 | PF-02341066 | crizotinib | Xalkori | |
| SCFR | AB1010 | masitinib | Masivet | |
| SRC | AZD0530 | saracatinib | ||
| BMS-354825 | dasatinib | Sprycel | ||
| KX2-391 | ||||
| XL228 | | |||
| SYK | R788 | fostamatinib | ||
| TORC1/2 | AZD8055 |
catalytic inhibitor |
||
| MLN0128, INK128 |
catalytic inhibitor |
|||
| OSI-027 |
catalytic inhibitor |
|||
| VEGFR | ABT-869 | linifanib | ||
| ENMD-2076 | ||||
| EXEL-2880, GSK1363089, XL880 | foretinib | |||
| HMPL-012 | sulfatinib | |||
| PTK 787, CGP 79787, ZK 222584 | vatalanib | |||
| TSU 68, SU6668 | orantinib | |||
| X-82 | inhibits all isoforms | |||
| XL647, KD019 | ||||
| VEGFR1/2/3 | AG-013736 | axitinib | Inlyta | |
| AMG706 | motesanib | |||
| BAY 73-4506 | regorafenib | Stivarga | ||
| BIBF1120 | nintedanib | Vargatef | ||
| E-3810 | ||||
| GW786034 | pazopanib | Votrient | ||
| HMPL-013 | fruquintinib | |||
| KRN951, AV-951 | tivozanib | |||
| MGCD265 | ||||
| VEGFR2 | AEE788, NVP-AEE788 | |||
| AP24534 | ponatinib | Iclusig | ||
| AZD2171 | cediranib | Recentin | ||
| AZD6474, ZD6474 | vandetanib | Zactima, Caprelsa | ||
| BAY 43-9006 | sorafenib | Nexavar | ||
| BMS-582664 | brivanib | |||
| BMS-690514, EVRI | ||||
| E7080 | lenvatinib | |||
| PKC412 | midostaurin | |||
| RAF265 | ||||
| SU-11248 | sunitinib | Sutent | ||
| XL184 | cabozantinib | Cometriq | ||
| XL820 | ||||
| YN968D1 | apatinib | |||
| VEGFR2/3 | BAY 57-9352 | telatinib | ||
| E7080 | lenvatinib | |||
| Therapeutic Antibodies | ||||
|---|---|---|---|---|
| Target | Development Name(s) | Generic Name(s) | Trade Name(s) |
Notes |
| BAFF | belimumab | Benlysta | ||
| CCR4 | KW-0761 | mogamulizumab | ||
| CD19/CD3 | MT103, MT-103, MEDI-538 | blinatumomab | ||
| CD20 | IDEC-102, IDEC-C2B8 | rituximab | Rituxan, Mabthera | |
| IDEC Y2B8 | ibritumomab tiuxetan | Zevalin | drug can be bound via tiuxetan to 111In or 90Y | |
| ofatumumab | Arzerra, HuMax-CD20 | |||
| CD22 | CAT-8015 | moxetumomab pasudotox | ||
| CD30 | SGN-35 | brentuximab | Adcetris | |
| CD38 | daratuzumab | HuMax-CD38 | ||
| CD52 | Campath | alemtuzumab | ||
| CD56 | IMGN901 | lorvotuzumab mertansine | ||
| CD74 | hLL1 | milatuzumab | ||
| CTLA4 | CP675,206 | tremelimumab | ||
| MDX-010, MDX-101, BMS-734016 | ipilimumab | Yervoy | ||
| EGFL7 | MEGF0444A | |||
| EGFR (HER1/ERBB1) | ABT-806, mAb-806 | |||
| ABX-EGF | panitumumab | Vectibix | ||
| h-R3, TheraCIM | nimotuzumab | |||
| IMC-11F8 | necitumumab | |||
| IMC-C225 | cetuximab | Erbitux | ||
| MEHD7945 A | ||||
| MM-151 | ||||
| RO5083945, GA201 | ||||
| Sym004 | ||||
| FZD7 | OMP-18R5 | vantictumab | ||
| HER2 (ERBB2/neu) | MM-111 | |||
| MOAB 2C4 | pertuzumab | Perjeta, Omnitarg | ||
| PRO132365 | ado-trastuzumab emtansine, T-DM1 | Kadcyla | ||
| trastuzumab | Herceptin | |||
| HER3 (ERBB3) | AV 203 | |||
| MEHD7945 A | ||||
| MM-111 | ||||
| MM-121, SAR256212 | ||||
| U3-1287, AMG 888 | ||||
| HGF | AMG 102 | rilotumumab | ||
| AV-299, SCH900105 | ficlatuzumab | |||
| IGF-1R | AMG-479 | ganitumab | ||
| BI 836845 | ||||
| BIIB022 | ||||
| CP-751871 | figitumumab | |||
| IMC-A12 | cixutumumab | |||
| MEDI-573 | ||||
| MK-0646 | dalotuzumab | |||
| IGF-2R | BI 836845 | |||
| MEDI-573 | ||||
| MET | LY2875358 | |||
| MetMAb, R05490258, OA-5D | onartuzumab | |||
| PD-1 | AMP-224 | |||
| BMS-936558, MDX-1106, ONO-4538 | nivolumab | |||
| CT-011 | pidilizumab | |||
| MK-3475 | ||||
| PD-L1 | MDX-1105, BMS-936559 | |||
| MPDL3280A, RG7446 | ||||
| PDGFRα | IMC-3G3 | ramucirumab | ||
| MEDI-575 | ||||
| PIGF | ziv-aflibercept | Zaltrap | ||
| TRAIL-R1/DR4,R2/D5 | AMG951, rhApo2L/TRAIL | dulanermin | ||
| TRAIL-R1/D4 | HGS-ETR1 | mapatumumab | ||
| TRAIL-R2/D5 | AMG-655 | conatumumab | ||
| HGS-ETR2 | lexatumumab | |||
| LBY135 | ||||
| PRO95780 | apomab | |||
| VEGFA | bevacizumab | Avastin | ||
| ziv-aflibercept | Zaltrap | |||
| VEGFB | ziv-aflibercept | Zaltrap | ||
| VEGFR2 | IMC-1121B | ramucirumab | ||
| Immunotherapies | ||||
|---|---|---|---|---|
| Target | Development Name(s) | Generic Name(s) | Trade Name(s) |
Notes |
| CTLA4 | CP675,206 | tremelimumab | ||
| MDX-010, MDX-101, BMS-734016 | ipilimumab | Yervoy | ||
| IL-6 | siltuximab | |||
| IL-6R | R-1569 | tocilizumab | Actemra | |
| IL-1β | ACZ885 | canakinumab | Ilaris | |
| PD-1 | AMP-224 | |||
| BMS-936558, MDX-1106, ONO-4538 | nivolumab | |||
| CT-011 | pidilizumab | |||
| MK-3475 | ||||
| PD-L1 | MDX-1105, BMS-936559 | |||
| MPDL3280A, RG7446 | ||||
| Other | interferon-alpha | |||
| APC8015 | sipuleucel-T | Provenge | ||
| TheraCys | BCG vaccine | |||
| TSF | aldesleukin | Proleukin | ||
| Chemotherapies | ||||
|---|---|---|---|---|
| Type of Chemotherapy | Subtype | Generic Name(s) | Trade Name(s) |
Notes |
| Alkylating Agents | Nitrogen mustard | bendamustine | Treanda, Ribomustin | |
| chlorambucil | Ambochlorin | |||
| cyclophosphamide | Clafen | |||
| ifosfamide | Cyfos | |||
| melphalan | Alkeran | |||
| palifosfamide tris | ||||
| Ethylenimines | thiotepa | Girostan | ||
| Nitrosoureas | carmustine | Becenum | ||
| lomustine | CeeNU | |||
| streptozocin | Zanosar | |||
| Alkyl sufonates | busulfan | Busulfex | ||
| Triazenes | dacarbazine | DTIC-Dome | ||
| temozolomide | Methazolastone | |||
| Platinum analogues | carboplatin | Paraplat | ||
| cisplatin | Platinol | |||
| oxaliplatin | Eloxatin | |||
| Other | procarbazine | Matulane | ||
| Topoisomerase II inhibitors | Anthracyclines | daunorubicin | Cerubidine | |
| liposomal daunorubicin | DaunoXome | |||
| doxorubicin | Adriamycin PFS | |||
| liposomal doxorubicin | Doxil | |||
| epirubicin | Ellence | |||
| idarubicin | Idamycin | |||
| valrubicin | Valstar | |||
| Epipodophyllotoxins | etoposide/etoposide phosphate | Toposar | ||
| teniposide | Vumon | |||
| Anthracenedione | mitoxantrone | Novantrone | ||
| Other | amonafide | |||
| Topoisomerase I inhibitors | Camptothecin derivatives | etirinotecan | ||
| irinotecan | Camptosar | |||
| topotecan | Hycamptin | |||
| Quinoline alkaloids | camptothecin | |||
| Antimicrotubule Agents | Epothilones | ixabepilone | Ixempra | |
| Vinca alkaloids | vinblastine | Velban, Velsar | ||
| vincristine | Vincasar PFS | |||
| liposomal vincristine | Marqibo | |||
| vinorelbine | Navelbine | |||
| Taxanes | paclitaxel | Taxol | ||
| albumin-bound paclitaxel, nab-paclitaxel | Abraxane | |||
| docetaxel | Taxotere | |||
| cabazitaxel | Jevtana | |||
| Halichondrin B analogue | eribulin mesylate | |||
| Antimetabolites | Folate antagonists | methotrexate | Abitrexate | |
| pemetrexed | Alimta | |||
| pralatrexate | Folotyn | |||
| raltitrexed | Tomudex | |||
| Purine analogues | cladribine | Leustatin | ||
| clofarabine | Clofarex | |||
| fludarabine | Fludara | |||
| mercaptopurine | Mercaptopurinum | |||
| nelarabine | Arranon | |||
| pentostatin | Nipent | |||
| thioguanine | Tabloid | |||
| Pyrimidine analogues | capecitabine | Xeloda | ||
| cytarabine | Cytosar-U | |||
| floxuridine | FUDF | |||
| fluorouracil | Adrucil | |||
| gemcitabine | Gemzar | |||
| Other | hydroxyurea | Droxia | ||
| Other | Antitumor antibiotic | bleomycin | Blenoxane | |
| dactinomycin | Cosmegen | |||
| mitomycin | Mitozytrex | |||
| Aspariginase derivatives | e. coli derived asparaginase | Cristanaspase | ||
| erwinia derived asparaginase | Erwinaze | |||
| pegaspargase | Oncaspar | |||
| Hypomethylating Agents | azacitidine | Mylosar | ||
| decitabine | Dacogen | |||
| Retinoic acid derivatives | alitretinoin | Panretin | ||
| bexarotene | Targretin | |||
| tretinoin | Aberel | |||
| Telomerase template antagonist | imetelstat | |||
| Other | arsenic trioxide | Trisenox |
||
| mitotane | Lysodren | |||
| trabectedin | Yondelis | |||
| denileukin diftitox | Ontak | |||
| octreotide | Sandostatin | |||
| dexamethasone/prednisone | Aeroseb-Dex | |||
| Hormonal Agents | ||||
|---|---|---|---|---|
| Type of Agent | Development Name | Generic Name(s) | Trade Name(s) |
Notes |
| Selective androgen receptor modulator (SARM) | GTX-024 | enobosarm | Osterine | |
| Androgen receptor antagonist | nilutamide | Nilandron, Anandron | ||
| bicalutamide | Casodex | |||
| flutamide | Eulexin, Apimid | |||
| MDV3100 | enzalutamide | Xtandi | ||
| Aromatase inhibitor | CGS 20267 | letrozole | Femara | |
| FCE-24304 | exemestane | Aromasin | ||
| anastrozole | Arimidex | |||
| Estrogen receptor antagonist | fulvestrant | Faslodex | ||
| Selective estrogen receptor modulator (SERM) | tamoxifen | Nolvadex | ||
| LY-139481 | raloxifene | Evista, Keoxifene | ||
| toremifene | Fareston | |||
| LH-RH analogues and antagonists | degarelix | Firmagon | ||
| leuprolide | Lupron | |||
| triptorelin | Decapeptyl | |||
| goserelin | Zoladex | |||
| Other | abiraterone | |||
| megestrol acetate | ||||
| estramustine | Emcyt, Estracyt | |||
| ketoconazole | ||||
| Other | ||||
|---|---|---|---|---|
| Target | Development Name(s) | Generic Name(s) | Trade Name(s) |
Notes |
| Ang1/Ang2 | AMG 386 | trebananib | ||
| Bcl-2 | ABT-263, ABT-737 | navitoclax | ||
| AT101 | ||||
| GX15-070 | obatoclax | |||
| G3139 | oblimerson | Genasense | ||
| CXCR4 | LY2510924 | |||
| Farnesyl protein transferase (FTase) | IND 58359 | tipifarnib | Zarnestra | |
| Gamma-secretase | MK0752 | |||
| HDAC | FK228 | romidepsin | Istodax | |
| LBH589 | panobinostat | Faridak | ||
| MK-0683 | vorinostat | Zolinza | ||
| MS-275, SNDX-275 | entinostat | |||
| PXD101 | belinostat | |||
| HSP90 | 17-AAG, KOS-953 | tanespimycin | ||
| AT13387 | ||||
| AUY922 | ||||
| Debio 0932 | ||||
| IPI-504 | retaspimycin | |||
| STA-9090 | ganetespib | |||
| Notch Pathway | MK0752 | |||
| PF-03084014 | ||||
| REGN421 | ||||
| RO4929097, R4733 | ||||
| PARP | ABT-888 | veliparib | ||
| AG-014699 , PF-01367338 | rucaparib | |||
| AZD2281 | olaparib | |||
| BSI-201 | iniparib | |||
| MK4827 | ||||
| PPAR-γ | CS 7017, RS5444 | |||
| Proteasome | LDP 341, MLN341, PS-341 | bortezomib | Velcade | |
| PR-171 | carfilzomib | Kyprolis | ||
| PTCH | GDC-0449 | vismodegib | Erivedge | |
| Smoothened | GDC-0449 | vismodegib | Erivedge | |
| LDE225 | erismodegib | |||
| LY2940680 | ||||
| Other | CC-4047 | pomalidomide | Pomalyst | thalidomide derivative |
| CC-5013 | lenalidomide | Revlimid | thalidomide analog | |
| thalidomide | Thalomid | |||
NOTE: To suggest additions or changes, please contact us here.
Last Updated: April 29, 2013
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