Associated Genetic Biomarkers
AKT1 Loss is present in 0.11% of AACR GENIE cases, with gastrointestinal stromal tumor, diffuse large B-cell lymphoma, not otherwise specified, bladder urothelial carcinoma, breast invasive ductal carcinoma, and dendritic cell tumor, not otherwise specified having the greatest prevalence .
AKT1 Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains AKT1 Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with AKT1 Loss in the inclusion eligibility criteria most commonly target malignant solid tumor .
Capivasertib and olaparib are the most frequent therapies in trials with AKT1 Loss as an inclusion criteria .
Significance of AKT1 Loss in Diseases
Malignant Solid Tumor +
AKT1 is altered in 1.89% of malignant solid tumor patients with AKT1 Loss present in 0.09% of all malignant solid tumor patients .
AKT1 Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains AKT1 Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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