Associated Genetic Biomarkers
AKT3 Loss is present in 0.08% of AACR GENIE cases, with diffuse large B-cell lymphoma, not otherwise specified, colon adenocarcinoma, neuroblastoma, uterine corpus leiomyosarcoma, and B-cell lymphoblastic leukemia/lymphoma having the greatest prevalence .
AKT3 Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains AKT3 Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with AKT3 Loss in the inclusion eligibility criteria most commonly target malignant solid tumor .
Capivasertib and olaparib are the most frequent therapies in trials with AKT3 Loss as an inclusion criteria .
Significance of AKT3 Loss in Diseases
Malignant Solid Tumor +
AKT3 is altered in 1.34% of malignant solid tumor patients with AKT3 Loss present in 0.04% of all malignant solid tumor patients .
AKT3 Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains AKT3 Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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