Associated Genetic Biomarkers
ARID1B Mutation is present in 3.96% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence .
ARID1B Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ARID1B Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ARID1B Mutation in the inclusion eligibility criteria most commonly target melanoma .
Niraparib is the most frequent therapy in trials with ARID1B Mutation as an inclusion criteria .
Significance of ARID1B Mutation in Diseases
ARID1B is altered in 7.2% of melanoma patients with ARID1B Mutation present in 6.44% of all melanoma patients .
ARID1B Mutation is an inclusion criterion in 1 clinical trial for melanoma, of which 1 is open and 0 are closed. Of the trial that contains ARID1B Mutation and melanoma as inclusion criteria, 1 is phase 2 (1 open) .
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