Associated Genetic Biomarkers
ATM P292L is present in 0.02% of AACR GENIE cases, with colon adenocarcinoma, adrenal cortex carcinoma, colorectal adenocarcinoma, endometrial endometrioid adenocarcinoma, and mantle cell lymphoma having the greatest prevalence .
ATM P292L serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain ATM P292L as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (0 open).
Trials with ATM P292L in the inclusion eligibility criteria most commonly target malignant solid tumor and small cell lung carcinoma .
Vx-803 and olaparib are the most frequent therapies in trials with ATM P292L as an inclusion criteria .
Significance of ATM P292L in Diseases
Malignant Solid Tumor +
ATM is altered in 5.8% of malignant solid tumor patients with ATM P292L present in 0.02% of all malignant solid tumor patients .
ATM P292L is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ATM P292L and malignant solid tumor as inclusion criteria, 1 is phase 1 (1 open) .
Small Cell Lung Carcinoma +
ATM is altered in 3.75% of small cell lung carcinoma patients .
ATM P292L is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains ATM P292L and small cell lung carcinoma as inclusion criteria, 1 is phase 2 (0 open) .
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