Associated Genetic Biomarkers
ATM S2394L is present in 0.02% of AACR GENIE cases, with bladder urothelial carcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, gallbladder carcinoma, and melanoma having the greatest prevalence .
ATM S2394L serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain ATM S2394L as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (0 open).
Trials with ATM S2394L in the inclusion eligibility criteria most commonly target malignant solid tumor and small cell lung carcinoma .
Vx-803 and olaparib are the most frequent therapies in trials with ATM S2394L as an inclusion criteria .
Significance of ATM S2394L in Diseases
Malignant Solid Tumor +
ATM is altered in 5.8% of malignant solid tumor patients with ATM S2394L present in 0.01% of all malignant solid tumor patients .
ATM S2394L is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ATM S2394L and malignant solid tumor as inclusion criteria, 1 is phase 1 (1 open) .
Small Cell Lung Carcinoma +
ATM is altered in 3.75% of small cell lung carcinoma patients .
ATM S2394L is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains ATM S2394L and small cell lung carcinoma as inclusion criteria, 1 is phase 2 (0 open) .
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