Associated Genetic Biomarkers
BRAF E586K is present in 0.02% of AACR GENIE cases, with cutaneous melanoma, melanoma, lung adenocarcinoma, bladder urothelial carcinoma, and ganglioglioma having the greatest prevalence .
BRAF E586K serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRAF E586K as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Trials with BRAF E586K in the inclusion eligibility criteria most commonly target malignant solid tumor .
Binimetinib and encorafenib are the most frequent therapies in trials with BRAF E586K as an inclusion criteria .
Significance of BRAF E586K in Diseases
Malignant Solid Tumor +
BRAF is altered in 6.59% of malignant solid tumor patients with BRAF E586K present in 0.01% of all malignant solid tumor patients .
BRAF E586K is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains BRAF E586K and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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