Associated Genetic Biomarkers
BRCA1 Frameshift is present in 0.32% of AACR GENIE cases, with breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, colon adenocarcinoma, invasive breast carcinoma, and lung adenocarcinoma having the greatest prevalence .
BRCA1 Frameshift serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRCA1 Frameshift as an inclusion criterion, 1 is phase 2 (1 open).
Trials with BRCA1 Frameshift in the inclusion eligibility criteria most commonly target breast carcinoma, ovarian carcinoma, primary peritoneal carcinoma, fallopian tube endometrioid adenocarcinoma, and high grade fallopian tube serous adenocarcinoma .
Radiation therapy, rucaparib, talazoparib, olaparib, and veliparib are the most frequent therapies in trials with BRCA1 Frameshift as an inclusion criteria .
Significance of BRCA1 Frameshift in Diseases
Non-Small Cell Lung Carcinoma +
BRCA1 is altered in 3.08% of non-small cell lung carcinoma patients with BRCA1 Frameshift present in 0.19% of all non-small cell lung carcinoma patients .
BRCA1 Frameshift is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains BRCA1 Frameshift and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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