Associated Genetic Biomarkers
BRCA2 Frameshift is present in 0.75% of AACR GENIE cases, with colon adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence .
BRCA2 Frameshift serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRCA2 Frameshift as an inclusion criterion, 1 is phase 2 (1 open).
Trials with BRCA2 Frameshift in the inclusion eligibility criteria most commonly target breast carcinoma, ovarian carcinoma, primary peritoneal carcinoma, fallopian tube endometrioid adenocarcinoma, and high grade fallopian tube serous adenocarcinoma .
Radiation therapy, rucaparib, talazoparib, olaparib, and veliparib are the most frequent therapies in trials with BRCA2 Frameshift as an inclusion criteria .
Significance of BRCA2 Frameshift in Diseases
Non-Small Cell Lung Carcinoma +
BRCA2 is altered in 4.24% of non-small cell lung carcinoma patients with BRCA2 Frameshift present in 0.35% of all non-small cell lung carcinoma patients .
BRCA2 Frameshift is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains BRCA2 Frameshift and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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