Associated Genetic Biomarkers
BRCA2 Nonsense is present in 0.42% of AACR GENIE cases, with lung adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, colon adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence .
BRCA2 Nonsense serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain BRCA2 Nonsense as an inclusion criterion, 2 are phase 2 (2 open).
Trials with BRCA2 Nonsense in the inclusion eligibility criteria most commonly target breast carcinoma, ovarian carcinoma, primary peritoneal carcinoma, fallopian tube endometrioid adenocarcinoma, and high grade fallopian tube serous adenocarcinoma .
Radiation therapy, olaparib, rucaparib, talazoparib, and durvalumab are the most frequent therapies in trials with BRCA2 Nonsense as an inclusion criteria .
Significance of BRCA2 Nonsense in Diseases
Prostate Carcinoma +
BRCA2 is altered in 4.91% of prostate carcinoma patients with BRCA2 Nonsense present in 0.81% of all prostate carcinoma patients .
BRCA2 Nonsense is an inclusion criterion in 1 clinical trial for prostate carcinoma, of which 1 is open and 0 are closed. Of the trial that contains BRCA2 Nonsense and prostate carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Non-Small Cell Lung Carcinoma +
BRCA2 is altered in 4.24% of non-small cell lung carcinoma patients with BRCA2 Nonsense present in 0.52% of all non-small cell lung carcinoma patients .
BRCA2 Nonsense is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains BRCA2 Nonsense and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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