Associated Genetic Biomarkers
BRIP1 Frameshift is present in 0.09% of AACR GENIE cases, with colon adenocarcinoma and breast invasive ductal carcinoma having the greatest prevalence .
BRIP1 Frameshift serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRIP1 Frameshift as an inclusion criterion, 1 is phase 2 (1 open).
Trials with BRIP1 Frameshift in the inclusion eligibility criteria most commonly target bladder carcinoma and urothelial carcinoma .
Olaparib is the most frequent therapy in trials with BRIP1 Frameshift as an inclusion criteria .
Significance of BRIP1 Frameshift in Diseases
Bladder Carcinoma +
Urothelial Carcinoma +
BRIP1 is mutated in 3.08% of urothelial carcinoma patients .
BRIP1 Frameshift is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains BRIP1 Frameshift and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.