Associated Genetic Biomarkers
BTK Mutation is present in 0.78% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence .
BTK Mutation serves as an inclusion eligibility criterion in 4 clinical trials, of which 3 are open and 1 is closed. Of the trials that contain BTK Mutation as an inclusion criterion, 1 is phase 1 (0 open) and 3 are phase 2 (3 open).
Trials with BTK Mutation in the inclusion eligibility criteria most commonly target chronic lymphocytic leukemia/small lymphocytic lymphoma and chronic lymphocytic leukemia .
Ibrutinib, venetoclax, and duvelisib are the most frequent therapies in trials with BTK Mutation as an inclusion criteria .
Significance of BTK Mutation in Diseases
Chronic Lymphocytic Leukemia +
BTK Mutation is an inclusion criterion in 2 clinical trials for chronic lymphocytic leukemia, of which 1 is open and 1 is closed. Of the trials that contain BTK Mutation and chronic lymphocytic leukemia as inclusion criteria, 1 is phase 1 (0 open) and 1 is phase 2 (1 open) .
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +
BTK Mutation is an inclusion criterion in 2 clinical trials for chronic lymphocytic leukemia/small lymphocytic lymphoma, of which 2 are open and 0 are closed. Of the trials that contain BTK Mutation and chronic lymphocytic leukemia/small lymphocytic lymphoma as inclusion criteria, 2 are phase 2 (2 open) .
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