Gene Location [1]
Variant Type

CD274 Amplification is present in 0.34% of AACR GENIE cases, with breast invasive ductal carcinoma, diffuse large B-cell lymphoma, not otherwise specified, lung adenocarcinoma, oral cavity squamous cell carcinoma, and cancer of unknown primary having the greatest prevalence [4].

Top Disease Cases with CD274 Amplification

Significance of CD274 Amplification in Diseases

Malignant Solid Tumor +

Diffuse Large B-Cell Lymphoma +

Penile Carcinoma +

Squamous Cell Carcinoma Of The Penis +

Gallbladder Carcinoma +

Gastric Carcinoma +

Biliary Tract Carcinoma +

Angiosarcoma +

Bladder Squamous Cell Carcinoma +

Bronchioloalveolar Carcinoma +

Cervical Clear Cell Adenocarcinoma +

Desmoid-Type Fibromatosis +

Double-Hit Lymphoma +

Esophageal Undifferentiated Carcinoma +

Gestational Trophoblastic Tumor +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

Lung Sarcomatoid Carcinoma +

Malignant Giant Cell Neoplasm +

Malignant Odontogenic Neoplasm +

Mucinous Tubular And Spindle Cell Carcinoma Of The Kidney +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Ovarian Small Cell Carcinoma, Hypercalcemic Type +

Pecoma +

Pancreatic Acinar Cell Carcinoma +

Pancreatic Cystadenocarcinoma +

Pancreatic Serous Cystadenocarcinoma +

Peripheral T-Cell Lymphoma +

Prostate Small Cell Carcinoma +

Prostate Squamous Cell Carcinoma +

Renal Pelvis Squamous Cell Carcinoma +

Small Intestinal Undifferentiated Carcinoma +

Transformed Non-Hodgkin Lymphoma +

Undifferentiated Gastric Carcinoma +

Ureter Squamous Cell Carcinoma +

Urethral Squamous Cell Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.