CDK4 Overexpression serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains CDK4 Overexpression as an inclusion criterion, 1 is phase 2 (1 open).
Trials with CDK4 Overexpression in the inclusion eligibility criteria most commonly target osteosarcoma and soft tissue sarcoma .
Palbociclib is the most frequent therapy in trials with CDK4 Overexpression as an inclusion criteria .
Significance of CDK4 Overexpression in Diseases
Soft Tissue Sarcoma +
CDK4 is altered in 2.41% of soft tissue sarcoma patients .
CDK4 Overexpression is an inclusion criterion in 1 clinical trial for soft tissue sarcoma, of which 1 is open and 0 are closed. Of the trial that contains CDK4 Overexpression and soft tissue sarcoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.