Associated Genetic Biomarkers
CDKN2A D108Y is present in 0.04% of AACR GENIE cases, with lung adenocarcinoma and bladder urothelial carcinoma having the greatest prevalence .
CDKN2A D108Y serves as an inclusion eligibility criterion in 4 clinical trials, of which 3 are open and 1 is closed. Of the trials that contain CDKN2A D108Y as an inclusion criterion, 4 are phase 2 (3 open).
Trials with CDKN2A D108Y in the inclusion eligibility criteria most commonly target glioblastoma, head and neck squamous cell carcinoma, and malignant solid tumor .
Abemaciclib, pembrolizumab, ribociclib, siremadlin, and surgery are the most frequent therapies in trials with CDKN2A D108Y as an inclusion criteria .
Significance of CDKN2A D108Y in Diseases
Malignant Solid Tumor +
CDKN2A is altered in 9.28% of malignant solid tumor patients with CDKN2A D108Y present in 0.04% of all malignant solid tumor patients .
CDKN2A D108Y is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A D108Y and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
Head And Neck Squamous Cell Carcinoma +
CDKN2A D108Y is an inclusion criterion in 1 clinical trial for head and neck squamous cell carcinoma, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A D108Y and head and neck squamous cell carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.