Associated Genetic Biomarkers
CDKN2A D74N serves as an inclusion eligibility criterion in 4 clinical trials, of which 3 are open and 1 is closed. Of the trials that contain CDKN2A D74N as an inclusion criterion, 4 are phase 2 (3 open).
Trials with CDKN2A D74N in the inclusion eligibility criteria most commonly target glioblastoma, head and neck squamous cell carcinoma, and malignant solid tumor .
Abemaciclib, pembrolizumab, ribociclib, siremadlin, and surgery are the most frequent therapies in trials with CDKN2A D74N as an inclusion criteria .
Significance of CDKN2A D74N in Diseases
Malignant Solid Tumor +
CDKN2A is altered in 9.28% of malignant solid tumor patients with CDKN2A D74N present in 0.02% of all malignant solid tumor patients .
CDKN2A D74N is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A D74N and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
Head And Neck Squamous Cell Carcinoma +
CDKN2A D74N is an inclusion criterion in 1 clinical trial for head and neck squamous cell carcinoma, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A D74N and head and neck squamous cell carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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