Associated Genetic Biomarkers
CDKN2A Fusion is present in 0.26% of AACR GENIE cases, with lung adenocarcinoma, pancreatic adenocarcinoma, esophageal adenocarcinoma, conventional glioblastoma multiforme, and squamous cell lung carcinoma having the greatest prevalence .
CDKN2A Fusion serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain CDKN2A Fusion as an inclusion criterion, 2 are phase 2 (1 open).
Trials with CDKN2A Fusion in the inclusion eligibility criteria most commonly target glioblastoma .
Abemaciclib, pembrolizumab, and surgery are the most frequent therapies in trials with CDKN2A Fusion as an inclusion criteria .
Significance of CDKN2A Fusion in Diseases
CDKN2A Fusion is an inclusion criterion in 2 clinical trials for glioblastoma, of which 1 is open and 1 is closed. Of the trials that contain CDKN2A Fusion and glioblastoma as inclusion criteria, 2 are phase 2 (1 open) .
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