Associated Genetic Biomarkers
CDKN2A L94P is present in 0.01% of AACR GENIE cases, with ampulla of vater pancreatobiliary type adenocarcinoma, gallbladder carcinoma, hypopharyngeal squamous cell carcinoma, pancreatic adenocarcinoma, and poorly differentiated carcinoma, NOS having the greatest prevalence .
CDKN2A L94P serves as an inclusion eligibility criterion in 3 clinical trials, of which 2 are open and 1 is closed. Of the trials that contain CDKN2A L94P as an inclusion criterion, 3 are phase 2 (2 open).
Trials with CDKN2A L94P in the inclusion eligibility criteria most commonly target glioblastoma, head and neck squamous cell carcinoma, and malignant solid tumor .
Abemaciclib, pembrolizumab, ribociclib, and siremadlin are the most frequent therapies in trials with CDKN2A L94P as an inclusion criteria .
Significance of CDKN2A L94P in Diseases
Head And Neck Squamous Cell Carcinoma +
CDKN2A is altered in 23.69% of head and neck squamous cell carcinoma patients with CDKN2A L94P present in 0.08% of all head and neck squamous cell carcinoma patients .
CDKN2A L94P is an inclusion criterion in 1 clinical trial for head and neck squamous cell carcinoma, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A L94P and head and neck squamous cell carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
CDKN2A is altered in 11.23% of malignant solid tumor patients with CDKN2A L94P present in 0.01% of all malignant solid tumor patients .
CDKN2A L94P is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains CDKN2A L94P and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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