Associated Genetic Biomarkers
CDKN2B Mutation is present in 0.25% of AACR GENIE cases, with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence .
CDKN2B Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains CDKN2B Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with CDKN2B Mutation in the inclusion eligibility criteria most commonly target malignant solid tumor .
Ceralasertib and olaparib are the most frequent therapies in trials with CDKN2B Mutation as an inclusion criteria .
Significance of CDKN2B Mutation in Diseases
Malignant Solid Tumor +
CDKN2B is altered in 7.98% of malignant solid tumor patients with CDKN2B Mutation present in 0.27% of all malignant solid tumor patients .
CDKN2B Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains CDKN2B Mutation and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
CDKN2B is altered in 10.07% of cholangiocarcinoma patients .
CDKN2B Mutation is an inclusion criterion in 1 clinical trial for cholangiocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains CDKN2B Mutation and cholangiocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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