Associated Genetic Biomarkers
CHEK2 Nonsense is present in 0.13% of AACR GENIE cases, with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, cutaneous melanoma, and lung adenocarcinoma having the greatest prevalence .
CHEK2 Nonsense serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains CHEK2 Nonsense as an inclusion criterion, 1 is phase 2 (1 open).
Trials with CHEK2 Nonsense in the inclusion eligibility criteria most commonly target prostate carcinoma .
Durvalumab and olaparib are the most frequent therapies in trials with CHEK2 Nonsense as an inclusion criteria .
Significance of CHEK2 Nonsense in Diseases
Prostate Carcinoma +
CHEK2 is altered in 1.03% of prostate carcinoma patients with CHEK2 Nonsense present in 0.09% of all prostate carcinoma patients .
CHEK2 Nonsense is an inclusion criterion in 1 clinical trial for prostate carcinoma, of which 1 is open and 0 are closed. Of the trial that contains CHEK2 Nonsense and prostate carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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