Associated Genetic Biomarkers
CXCR4 Mutation is present in 0.48% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, diffuse large B-cell lymphoma, not otherwise specified, and conventional glioblastoma multiforme having the greatest prevalence .
CXCR4 Mutation serves as an inclusion eligibility criterion in 3 clinical trials, of which 2 are open and 1 is closed. Of the trials that contain CXCR4 Mutation as an inclusion criterion, 1 is phase 1/phase 2 (1 open), 1 is phase 2/phase 3 (0 open), and 1 is phase 3 (1 open).
Trials with CXCR4 Mutation in the inclusion eligibility criteria most commonly target waldenstrom macroglobulinemia .
Ibrutinib, carfilzomib, and ulocuplumab are the most frequent therapies in trials with CXCR4 Mutation as an inclusion criteria .
Significance of CXCR4 Mutation in Diseases
Waldenstrom Macroglobulinemia +
CXCR4 Mutation is an inclusion criterion in 2 clinical trials for waldenstrom macroglobulinemia, of which 2 are open and 0 are closed. Of the trials that contain CXCR4 Mutation and waldenstrom macroglobulinemia as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 1 is phase 3 (1 open) .
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome (WHIMS) +
CXCR4 Mutation is an inclusion criterion in 1 clinical trial for warts, hypogammaglobulinemia, infections, and myelokathexis syndrome (WHIMS), of which 0 are open and 1 is closed. Of the trial that contains CXCR4 Mutation and warts, hypogammaglobulinemia, infections, and myelokathexis syndrome (WHIMS) as inclusion criteria, 1 is phase 2/phase 3 (0 open) .
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