Associated Genetic Biomarkers
DAXX Frameshift is present in 0.13% of AACR GENIE cases, with pancreatic neuroendocrine neoplasm, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, neuroendocrine tumor, NOS, and conventional glioblastoma multiforme having the greatest prevalence .
DAXX Frameshift serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains DAXX Frameshift as an inclusion criterion, 1 is phase 1 (1 open).
Trials with DAXX Frameshift in the inclusion eligibility criteria most commonly target malignant solid tumor .
Vx-803 is the most frequent therapy in trials with DAXX Frameshift as an inclusion criteria .
Significance of DAXX Frameshift in Diseases
Malignant Solid Tumor +
DAXX is altered in 1.57% of malignant solid tumor patients with DAXX Frameshift present in 0.14% of all malignant solid tumor patients .
DAXX Frameshift is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains DAXX Frameshift and malignant solid tumor as inclusion criteria, 1 is phase 1 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.