EGFR Exon 18 Deletion
Associated Genetic Biomarkers
EGFR Exon 18 Deletion is present in 0.07% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, endometrial endometrioid adenocarcinoma, glioblastoma, and squamous cell lung carcinoma having the greatest prevalence .
EGFR Exon 18 Deletion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EGFR Exon 18 Deletion as an inclusion criterion, 1 is phase 2 (1 open).
Trials with EGFR Exon 18 Deletion in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Dacomitinib is the most frequent therapy in trials with EGFR Exon 18 Deletion as an inclusion criteria .
Significance of EGFR Exon 18 Deletion in Diseases
Non-Small Cell Lung Carcinoma +
EGFR is altered in 22.89% of non-small cell lung carcinoma patients with EGFR Exon 18 Deletion present in 0.21% of all non-small cell lung carcinoma patients .
EGFR Exon 18 Deletion is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR Exon 18 Deletion and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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