Associated Genetic Biomarkers
EGFR Fusion is present in 0.43% of AACR GENIE cases, with lung adenocarcinoma, glioblastoma, conventional glioblastoma multiforme, colon adenocarcinoma, and non-small cell lung carcinoma having the greatest prevalence .
EGFR Fusion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EGFR Fusion as an inclusion criterion, 1 is phase 2 (1 open).
Trials with EGFR Fusion in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Tarloxotinib is the most frequent therapy in trials with EGFR Fusion as an inclusion criteria .
Significance of EGFR Fusion in Diseases
Non-Small Cell Lung Carcinoma +
EGFR Fusion is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR Fusion and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
EGFR Fusion is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains EGFR Fusion and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.