Associated Genetic Biomarkers
EGFR K860I is present in 0.02% of AACR GENIE cases, with lung adenocarcinoma, breast invasive lobular carcinoma, and squamous cell lung carcinoma having the greatest prevalence .
EGFR K860I serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EGFR K860I as an inclusion criterion, 1 is phase 1 (1 open).
Trials with EGFR K860I in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma and small cell lung carcinoma .
Alisertib and osimertinib are the most frequent therapies in trials with EGFR K860I as an inclusion criteria .
Significance of EGFR K860I in Diseases
Non-Small Cell Lung Carcinoma +
EGFR is altered in 22.89% of non-small cell lung carcinoma patients with EGFR K860I present in 0.04% of all non-small cell lung carcinoma patients .
EGFR K860I is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR K860I and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (1 open) .
Small Cell Lung Carcinoma +
EGFR is altered in 9.38% of small cell lung carcinoma patients .
EGFR K860I is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR K860I and small cell lung carcinoma as inclusion criteria, 1 is phase 1 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.