Associated Genetic Biomarkers
EGFR R451C is present in 0.10% of AACR GENIE cases, with conventional glioblastoma multiforme and oropharyngeal squamous cell carcinoma having the greatest prevalence .
EGFR R451C serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain EGFR R451C as an inclusion criterion, 2 are phase 2 (2 open).
Trials with EGFR R451C in the inclusion eligibility criteria most commonly target colorectal adenocarcinoma .
Panitumumab, regorafenib, and trifluridine/tipiracil hydrochloride are the most frequent therapies in trials with EGFR R451C as an inclusion criteria .
Significance of EGFR R451C in Diseases
Colorectal Adenocarcinoma +
EGFR is altered in 3.25% of colorectal adenocarcinoma patients .
EGFR R451C is an inclusion criterion in 2 clinical trials for colorectal adenocarcinoma, of which 2 are open and 0 are closed. Of the trials that contain EGFR R451C and colorectal adenocarcinoma as inclusion criteria, 2 are phase 2 (2 open) .
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